Pelletization by Extrusion Spheronization Technique: An Excipient Review

Jadhav, Namdeo; Irny, Preeti; Mokashi, Ashwini; Souche, Pravin; Paradkar, Anant

doi:10.2174/2210303111202020132

Cited by 3 publications

(5 citation statements)

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“…The use of crosspovidone with negligible water added, removes the necessity of binder addition. Crosspovidone imparts shorter dissolution time as compared to MCC due to its superior disintegration property [ 64 , 65 ].…”

Section: Impact Of Materials Attributesmentioning

confidence: 99%

“…The most preferable processing can be done at temperature above the M.P. of semi-crystalline polymers or [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ] °C above the glass transition temperature Tg of amorphous polymers, but below the M. P. of the crystalline API [ 80 , 81 ].…”

Section: Processing Challengesmentioning

confidence: 99%

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Quality aspects in the development of pelletized dosage forms

Agrawal

Fernandes

Shaikh

et al. 2022

Heliyon

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Section: Impact Of Materials Attributesmentioning

confidence: 99%

Section: Processing Challengesmentioning

confidence: 99%

Quality aspects in the development of pelletized dosage forms

Agrawal

Fernandes

Shaikh

et al. 2022

Heliyon

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“…39 Accurately weighed quantities of ibuprofen (100 mg), microcrystalline cellulose quantity (MCC 100-300 mg) and CMTSP (300 to 500 mg) were mixed in planetary mixer (Avon, India) in increased geometric proportion. Granulating liquid, 10% w/v aqueous dispersion of PVP K30 was added slowly to the powder blend, which was then mixed until a homogeneous, cohesive and plastic mass was obtained.…”

Section: Formulation Of Drug Loaded Pelletsmentioning

confidence: 99%

“…It was observed that addition of CMTSP to MCC provided a moist environment to the pellets, thus imparted a suitable binding strength to the pellets due to its viscous nature. 39 As the concentration of CMTSP was increased, the binding strength was imparted to pellets which in turn increased its crushing strength.…”

Section: Stability Studymentioning

confidence: 99%

Carboxymethyl Tamarind Seed Kernel Polysaccharide Formulated into Pellets to Target at Colon

Pandit¹,

Waychal²,

Sayare³

et al. 2018

IJPER

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Objective: Tamarind seed polysaccharide (TSP) modifying to carboxymethyl tamarind seed kernel polysaccharide (CMTSP) could be potential polymer over synthetic one to target colon diseases. Ibuprofen was loaded in CMTSP to achieve colon targeted sustained action of pellets due to viscous nature of CMTSP. Methods: Ibuprofen loaded CMTSP pellets prepared by extrusion spheronization technique were optimized using three-level two-factor full factorial design. Results: Higher was the amount of CMTSP; better was the crushing strength of pellets, needed to target at the colon. in vitro dissolution test of the pellets at pH 1.2, 6.8 and 7.4 phosphate buffer showed drug release within 10 h. Further, the effect of enzyme induced in the colon portion of rat, in response to fed CMTSP and TSP, was carried out by performing dissolution study of pellets at 2 and 4% w/v of rat caecal matter in an anaerobic environment. The optimal calculated parameters were CMTSP and MCC, each at 300 mg, with highest crushing strength (23.6 N) and drug release (98%) within 9 h in presence of rat caecal content (4% w/v). Scanning electron microscopy revealed the spherical nature of pellets with rough surface and small pore openings for the drug release. Conclusion: Ibuprofen loaded pellets of CMTSP were successfully targeted at colon, due to increase in viscosity and decrease in swelling index of CMTSP than TSP.

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“…Pelletization involves size enlargement process and if the final agglomerates are spherical in shape in size range of 0.5-2.0 mm, they are called pellets. [1,2] Using a multiple-unit dosage form, pellets offer several advantages: Pellets disperse freely in the gastrointestinal tract and thus maximize drug absorption, reduce peak plasma fluctuations, and minimize side effects; high local concentrations of drug are avoided; there is flexibility in the development of oral dosage forms as pellets, so different drug substances (e.g., incompatible drugs) can be formulated and blended into a single dosage form; and immediate-and controlled-release pellets can be mixed to achieve the desired release pattern. [3][4][5] This present study was aimed to prepare extended release pellets of torsemide by extrusion-spheronization method.…”

mentioning

confidence: 99%

Untitled

Karra¹

2018

AJP

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Aim and Objective: The main objective of this study was to formulate extended release pellets of torsemide, a pyridine-sulfonyl urea type loop diuretic. Materials and Methods: The preparations of torsemide pellets were prepared by extrusion-spheronization method. The prepared pellets were then coated with ethyl cellulose of different grades and Eudragit L30 D 55 and Eudragit NM 30 D grades at different concentrations as release retardant polymers using fluid bed processor, in this formulation hydroxypropyl methylcellulose used as a pore former and binder, microcrystalline cellulose PH101 as diluents and water used as a solvent. Results: The prepared pellets were evaluated for drug content, in vitro dissolution, differential scanning caloriemetry (DSC), Fourier transforms infrared (FTIR), and scanning electron microscopy (SEM). The drug release was extended up to 24 h and drug release was depended on polymer grade and polymer proportion. The optimized formulation showed 99 ± 0.11 release in 24 h. The DSC and FTIR studies were showed the compatibility of the drug with a polymer, i.e., no drug-polymer interaction. Using SEM, it was shown that the torsemide pellets were porous and spherical in shape. Accelerated stability studies showed good similarity with the initial formulation indicated good stability for 6 months. In vivo, pharmacokinetic studies were conducted in rabbits by parallel design and pharmacokinetic parameters were calculated. Conclusion: By the above results, it can be concluded that the above-prepared pellets of torsemide could be able to extend the drug release by avoiding problems such as dose dumping, more gastric residence time, and improve the patient compliance. In vivo studies in rabbits were shown the increased half-life and bioavailability for a long duration.

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Pelletization by Extrusion Spheronization Technique: An Excipient Review

Cited by 3 publications

References 0 publications

Quality aspects in the development of pelletized dosage forms

Quality aspects in the development of pelletized dosage forms

Carboxymethyl Tamarind Seed Kernel Polysaccharide Formulated into Pellets to Target at Colon

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