Pemphigus Associated with Metastatic Carcinoid

Abstract

Patients with pemphigus are occasionally associated with neoplasms. We report a case of pemphigus with carcinoid. To our knowledge, this is the first case of coexistence of pemphigus and carcinoid.

An unusual occurrence of gastric adenocarcinoma in pemphigus vulgaris

“…In the literature, only one patient has been reported with pemphigus vulgaris associated with carcinoid tumor of the liver metastasized to the stomach 3 . As far as we are aware, the case presented here is the first report of the association of pemphigus vulgaris and adenocarcinoma of the stomach.…”

“…The relationship between pemphigus vulgaris and internal malignancy has also been debated for some time. Previous publications have reported associations between pemphigus vulgaris and lymphomas (Hodgkin and non‐Hodgkin lymphoma), thymoma, malignant melanoma, Kaposi's sarcoma, and malignancies of the lung and stomach (metastasis of liver carcinoid) 2,3,5 . In a study performed by Ogawa et al ., 1 the incidence rate of internal malignancies (most frequently detected carcinoma was lung cancer) was 5% in patients with pemphigus.…”

“…Bullous skin diseases, such as bullous pemphigoid, cicatricial pemphigoid, and paraneoplastic pemphigus, are associated with underlying malignant neoplasms 1–4 . The relationship between pemphigus vulgaris and internal malignancy has also been debated for some time.…”

Erythema nodosum associated with carcinoid tumour

“…Paraneoplastic dermatoses or immunological diseases such as sarcoidosis, 5 neurofibromatosis, 6 pemphigus 7 and membranous glomerulonephropathy 8 are associated with malignant carcinoid tumour. The underlying mechanism of these cases is unclear but is most likely due to the deposition of immune complexes.…”