Pemphigus vulgaris and squamous cell carcinoma of the lung

Barnadas, M. A.; Gelpí, Carmen; Rodríguez, José; González, MA; Moragas, José M. de

doi:10.1016/s0190-9622(89)80272-5

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Some studies have reported an association between PV and malignancies of different histogenesis (lymphoma, thymoma, and leukemia). 2,[8][9][10][11][12] whereas a few reports have described OSCC arising in acantholytic bullous disease. [15][16][17] PV is histologically characterized by rounded acantholytic cells with intensely eosinophilic cytoplasm, pyknotic nuclei, and perinuclear halos.…”

Section: Discussionmentioning

confidence: 99%

“…The finding of dysplasia in oral epithelium may herald an oral squamous cell carcinoma (OSCC) or a high-risk oral potential malignant lesion (OPML) and PV has been associated with malignancies of different histogenesis. 2,[8][9][10][11][12] Conversely, severe inflammation may induce reactive epithelial cell changes that mimic dysplasia. The present report describes the management of a patient with PV presenting unusual histological signs of high-grade dysplasia.…”

Section: Introductionmentioning

confidence: 99%

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Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris

et al. 2016

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This report describes the management of an unusual case of oral pemphigus vulgaris (PV). The patient was referred for a painful single bullous lesion together with a small proliferative area localized in the soft palate. Histology and direct immunofluorescence data were consistent for PV but disclosed unusual signs of high-grade dysplasia in the proliferative area. At surgical removal of the dysplastic area 1 week after the start of cortisone therapy there was no evidence of dysplasia. Histological signs of high-grade dysplasia in oral mucosa are often associated with concurrent or subsequent carcinoma. However, severe inflammation may induce reactive epithelial cell changes and hence mimic histologic dysplasia. Pathologic evaluation of dysplasia in an inflammatory disease like PV may be a diagnostic challenge and a careful pathological evaluation is advisable before choosing between surgical and medical approach.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris

et al. 2016

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“…Previous publications have reported squamous cell lung carcinoma associated with isolated pemphigus vulgaris of the skin or with the combination of pemphigus vulgaris, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy. 5,11 Gibson et al 12 reported a patient with antiepiligrin cicatricial pemphigoid, a rare subset of cicatricial pemphigoid, who experienced worsening symptoms simultaneously with the presentation of lung carcinoma. The antiepiligrin cicatricial pemphigoid involved the oral and conjunctival mucosa and was complicated by unilateral symblepharon formation.…”

Section: Discussionmentioning

confidence: 99%

Bronchogenic Squamous Cell Carcinoma Presenting as Cicatrizing Conjunctivitis

Vroman

Breckenridge

Solomon

et al. 2006

Cornea

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“…Lung cancer has been reported in coexistence with wide range of ABD: PV [17,27,28], PNP [29], pemphigus vegetans [30,31], pemphigus herpetiformis [32], IgA pemphigus [33], BP [34] and MMP [35]. In some BP cases, tumor resection led to complete recovery [36] supporting the thesis of close interrelation of the diseases.…”

Section: Malignancies Associated With Abdmentioning

confidence: 97%