With the Multiple Trips condition, the results obtained for the optimal distance route that starts and stops at PT. Tirta Investama Medan with Clarke Wright Algorithm at t = 1 is 22 km and at t = t + 1 is 15.2 km. While the optimal travel distance route with the Sequential Insertion Algorithm at t = 1 is 15.05 km, and at t = t + 1 is 22.9 km. Clarke Wright Algorithm looks for an optimal solution to get the best route, while Sequential Insertion Algorithm has an excess in the election of a customer by considering customer position with available insertion track location until all customer have been assigned. The Clarke Wright Algorithm obtained a total distance of 37.2 km. In comparison, the Sequential Insertion Algorithm solution obtained a total distance of 37.95 km. It can be concluded that the route formed using the Clarke Wright Algorithm in this case is more effective than using the Sequential Insertion Algorithm.