In 2013, the Indonesian government implemented Curriculum 2013 (C-13). C-13 requires applying a scientific approach in the learning process. This research aimed to describe the implementation of the scientific approach and see how application of the scientific approach in learning biology. The research sample consisted of 158 students from three senior high schools in Martapura, South Sumatra. The instrument used in this study was a questionnaire that was distributed to respondents via Google form. The data were subsequently analysed with descriptive quantitative. The result of the percentage of student activities in the biology learning process is a good category in conducting the scientific approach is 66.73%. The results of percentage of the level of ease and difficulty in implementing the scientific approach were as follows: (1) Observing (M1) was 76.58%, (2) Asking questions (M2) was 57%, (3) Doing experiments (M3) was 62.6%, (4) Reasoning (M4) was 30.3%, and (5) Communicating (M5) was 21.5%. Therefore, it's was concluded that based on the various biological problems that arise, it is known that the application of the scientific approach has very important to improving the soft skills and hard skills of students in learning biology.