Penetration of ceftriaxone and cefoperazone into bile and gallbladder tissue in patients with acute cholecystitis

Orda, Ruben; Berger, Stephen A.; Levy, Yaron Y.; Shnaker, Ali; Gorea, Alfred

doi:10.1007/bf01299860

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Furthermore, only limited recent evidence is available on the biliary excretion of cephalosporins and fluoroquinolones, the antibiotics prescribed most commonly to treat ACC. It is unclear whether these antibiotics can achieve a therapeutic dose in the bile, especially in biliary obstruction.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of antibiotic treatment for acute calculous cholecystitis

Dijk

Reuver

Tasma

et al. 2016

British Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Systematic review of antibiotic treatment for acute calculous cholecystitis

Dijk

Reuver

Tasma

et al. 2016

British Journal of Surgery

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“…For reference, Table 2 shows antimicrobial agents with good penetration of the gallbladder wall (level 3b-4). [13][14][15][16] The usefulness of biliary wall penetration for the selection of therapeutic antimicrobials in acute…”

Section: Q5 Should Penetration Into the Bile Or Gallbladder Wall Be mentioning

confidence: 99%

“…However, there are no clinical or experimental data to support this. For reference, Table 2 shows antimicrobial agents with good penetration of the gallbladder wall (level 3b–4) …”

Section: Introductionmentioning

confidence: 99%

Antimicrobial therapy for acute cholecystitis: Tokyo Guidelines

Yoshida

Takada

Kawarada

et al. 2007

J Hepatobiliary Pancreat Surg

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Acute cholecystitis consists of various morbid conditions, ranging from mild cases that are relieved by the oral administration of antimicrobial drugs or that resolve even without antimicrobials to severe cases complicated by biliary peritonitis. Microbial cultures should be performed by collecting bile at all available opportunities to identify both aerobic and anaerobic organisms. Empirically selected antimicrobials should be administered. Antimicrobial activity against potential causative organisms, the severity of the cholecystitis, the patient’s past history of antimicrobial therapy, and local susceptibility patterns (antibiogram) must be taken into consideration in the choice of antimicrobial drugs. In mild cases which closely mimic biliary colic, the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is recommended to prevent the progression of inflammation (recommendation grade A). When causative organisms are identified, the antimicrobial drug should be changed for a narrower-spectrum antimicrobial agent on the basis of the species and their susceptibility testing results.

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“…(1,(3)(4)(5)(6). Antibiotics, such as fluoroquinolones (e.g., ciprofloxacin [CIP]), carbapenems (e.g., meropenem [MEM]), and tigecycline (TGC), have been considered for treatment and are highly effective against E. coli (3,(7)(8)(9). Furthermore, TGC as well as linezolid (LZD), a protein synthesis inhibitor, is effective against other Gram-positive bacteria, namely, Enterococcus faecalis and Enterococcus faecium (9,10).…”

mentioning

confidence: 99%

“…Furthermore, TGC as well as linezolid (LZD), a protein synthesis inhibitor, is effective against other Gram-positive bacteria, namely, Enterococcus faecalis and Enterococcus faecium (9,10). Even though the actual benefit of antimicrobials for the treatment of biliary tract infections has been heavily debated, the employed antibiotic substances have found widespread use due to their spectrum of activity and their ability to penetrate the gallbladder wall, thereby reaching the bile (3,7,8,11).…”

mentioning

confidence: 99%

Human Bile Reduces Antimicrobial Activity of Selected Antibiotics against Enterococcus faecalis and Escherichia coli In Vitro

Wulkersdorfer

Jaros

Eberl

et al. 2017

Antimicrob Agents Chemother

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It has been known from previous studies that body fluids, such as cerebrospinal fluid, lung surfactant, and urine, have a strong impact on the bacterial killing of many anti-infective agents. However, the influence of human bile on the antimicrobial activity of antibiotics is widely unknown. Human bile was obtained and pooled from 11 patients undergoing cholecystectomy. After sterilization of the bile fluid by gamma irradiation, its effect on bacterial killing was investigated for linezolid (LZD) and tigecycline (TGC) against Enterococcus faecalis ATCC 29212. Further, ciprofloxacin (CIP), meropenem (MEM), and TGC were tested against Escherichia coli ATCC 25922. Time-kill curves were performed in pooled human bile and MuellerHinton broth (MHB) over 24 h. Bacterial counts (in CFU per milliliter after 24 h) of bile growth controls were approximately equal to MHB growth controls for E. coli and approximately 2-fold greater for E. faecalis, indicating a promotion of bacterial growth by bile for the latter strain. Bile reduced the antimicrobial activity of CIP, MEM, and TGC against E. coli as well as the activity of LZD and TGC against E. faecalis. This effect was strongest for TGC against the two strains. Degradation of TGC in bile was identified as the most likely explanation. These findings may have important implications for the treatment of bacterial infections of the gallbladder and biliary tract and should be explored in more detail.

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Penetration of ceftriaxone and cefoperazone into bile and gallbladder tissue in patients with acute cholecystitis

Cited by 8 publications

References 11 publications

Systematic review of antibiotic treatment for acute calculous cholecystitis

Systematic review of antibiotic treatment for acute calculous cholecystitis

Antimicrobial therapy for acute cholecystitis: Tokyo Guidelines

Human Bile Reduces Antimicrobial Activity of Selected Antibiotics against Enterococcus faecalis and Escherichia coli In Vitro

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