The postpartum period is a transitional period of changing roles for parents. Postpartum mothers need to have confidence in their ability to care for and nurture babies. Psychosocial conditions are one of the causes of problems in achieving her new role as a mother and babysitting. The study's focus was to determine the relationship of psychosocial conditions with parenting selfefficacy among postpartum mothers. This study is a correlational quantitative study with a cross-sectional approach. Sampling using purposive sampling of 107 respondents in postpartum mothers. The instrument used to measure psychosocial conditions uses the postnatal risk questionnaire (PNRQ) instrument and the parenting self-efficacy using the self-efficacy parenting scale (PSES) instrument. The statistical test in this study is spearman rank. The results showed that postpartum mothers had psychosocial conditions at risk of 36 (33.6%) and were not at risk by 71 (66.4%). Postpartum mothers had high selfefficacy parenting 98 (91.6%) and low 9 (8.4%). The results of the statistical test showed p-value= 0.000 and correlation coefficient= 0.426. There is a significant association of psychosocial conditions with self-efficacy parenting in postpartum mothers. Nurses need to identify the psychosocial condition of postpartum mothers and improve parenting self-efficacy towards the care of mothers and their babies.