PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP AKTIVITAS ANALGESIK DAN ANTIINFLAMASI MELALUI EKSPRESI ENZIM SIKLOOKSIGENASE

Sulistyawati, Rini; Pratiwi, Pramita Yulli

doi:10.12928/pharmaciana.v6i1.3043

Cited by 7 publications

(8 citation statements)

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“…18 Another study conducted by Sulistyawati found that the ethanol extract of Moringa leaves orally could inhibit COX-2 expression at a dose of 140 mg/kg BW with anti-inflammatory power of 24.30±2.960% was able to reduce COX-2 expression 46.37±6.434% in mice. 19 Research by Arulselvan et al found that Moringa leaf extract could inhibit the expression of COX-2, iNOS, TNF-α, and IL-1-β in lipopolysaccharide-induced macrophages. 8 The results of the phytochemical analysis of the content of Moringa leaf extract (data not shown) in this study found the presence of tannin compounds but no flavonoid compounds.…”

Section: Discussionmentioning

confidence: 99%

Application of Moringa Oleifera leaves extract cream inhibits paw edema in white male Wistar rat (Rattus norvegicus) induced by carrageenan 1%

2022

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Introduction: Inflammation is the body's response to body tissue injury characterized by swelling or edema. Moringa oleifera is known to have many benefits as herbal medicine. Moringa oleifera leaves have been shown to have anti-inflammatory activity. The polyphenol content in Moringa leaves, such as flavonoids and tannins, has been observed as a potential anti-inflammatory.Methods: Thirty white male Wistar rats were randomly divided into five groups. Group 0 (negative control group) was given base cream, group 1 (positive control) was given 2.5% hydrocortisone cream, group 2 was given 10% moringa leaves extract cream, group 3 was given 12% moringa leaves extract cream, and group 4 was given 14% moringa leaves extract cream. One hour after treatment was applied in the plantar area, all mice were induced with 0.1 ml of 1% carrageenan. The thickness of the rat paw edema was measured every 1 hour for 6 hours using a caliper.Results: This study showed a significant difference in rat paw edema between the base cream and the entire treatment groups (p<0.05). There was no significant difference between the 2.5% hydrocortisone cream group and the 10%, 12%, and 14% moringa leaves extract cream group (p>0.05). The 14% cream extract had the largest paw edema inhibition among other moringa leaves extract creams which were 27.4%.Conclusion: This study concludes that 10%, 12%, and 14% of moringa leaves extract cream have anti-inflammatory effects with higher concentrations resulting in better efficacy.

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Section: Discussionmentioning

confidence: 99%

Application of Moringa Oleifera leaves extract cream inhibits paw edema in white male Wistar rat (Rattus norvegicus) induced by carrageenan 1%

2022

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“…13 98 contain flavonoids, whereas the n-hexane extract did not contain both alkaloids and flavonoids [18]. However, other study showed that the extract of Moringa leaves macerated in ethanol contained flavonoids and polyphenols [19]. The distilled water extract also contained steroids, triterpenoids, flavonoids, saponins, phenols, and tannins [12].…”

Section: Fig 3: Inhibition Zone Of Ethanol Extract (Upper Row) and Distilled Water Extract (Bottom Row)mentioning

confidence: 99%

Inhibitory Activity of Distilled water and Ethanol Extracts of Moringa oleifera Leaves Against Enterobacter aerogenes

Shafira¹,

Metusalach²,

Amir³

2021

IJEAB

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Enterobacter aerogenes is one of the bacteria that has an important role in converting histidine to histamine in fish. When consumed, histamine in fish can cause poisoning and even death. The growth of bacteria that cause damage to fish can be inhibited in several ways, including the addition of compounds that have the potential to act as bacteriostatic or even bactericide. One of the plants that has the potential as a source of bactericide compounds is drumstic tree (Moringa oleifera Lamk.). This study aimed to determine the effectiveness of several concentrations of Moringa leaves extract using distilled water and ethanol in the inhibition of Enterobacter aerogenes bacteria as a histamine producer. The results showed that distilled water and ethanol extracts of Moringa leaves had an effective inhibition against Enterobacter aerogenes. The distilled water extract at a 40% concentration produced the largest inhibition zone (14.73 cm) while that of the ethanol extract at a 40% concentration was 10.57 cm. The distilled water extract of Moringa leaves is suitable for use because it is cheap, practical, safe for consumption and does not leave any unsafe residue on food.

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“…(2) Ekstraksi senyawa aktif telah dilakukan pada daun kelor dengan menggunakan pelarut yang berbeda-beda. Hasil penelitian uji skrining fitokimia ekstrak daun kelor (3) menunjukkan bahwa ekstrak daun kelor dengan pelarut etanol metode maserasi mengandung senyawa flavonoid dan polifenol. Kedua senyawa tersebut telah dibuktikan secara kromatografi lapis tipis (KLT).…”

Section: Pendahuluanunclassified

Identifikasi Senyawa Kimia Dan Nilai Gizi Ekstrak Air Daun Kelor (Moringa Oleifera L.) Sebagai Pengawet Alami Mie Basah

Rachmawati

Suriawati²

2019

SANITAS

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Moringa leaves or referred to Moringa oleifera Lam. are belong to the Moringaceae tribe. This plant is reported to have antibacterial activity and high nutritional value. To be used as an active ingredient in food preparations, it needs to be made in the form of extracts. The study aims to determine the characteristics of Moringa leaf water extract. In this study, Moringa leaves were extracted with a water solvent. Chemical characterization of Moringa leaf extract includes qualitative phytochemical tests and nutritional values (water content, ash, protein, fat, and carbohydrate). Whereas in microbiology, they include microbial contamination (Total Plate Count and Total Yeast and Mold Count). The results of characterization testing of the extracts showed that the water extract of Moringa leaves contain active compounds: flavonoids, phenols, triterpenoids/steroids, saponins, and tannins. Microbial contamination contained in the water extract of Moringa leaves are Total Plate Count value of 0 colonies/g and Mold/Yeast count value of 0 colonies/g and contain nutritional values such as water (75.85%), ash (3.87%), protein (6.27%), fat (<2.20 %) and carbohydrate (14.01%).

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PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP AKTIVITAS ANALGESIK DAN ANTIINFLAMASI MELALUI EKSPRESI ENZIM SIKLOOKSIGENASE

Cited by 7 publications

References 1 publication

Application of Moringa Oleifera leaves extract cream inhibits paw edema in white male Wistar rat (Rattus norvegicus) induced by carrageenan 1%

Application of Moringa Oleifera leaves extract cream inhibits paw edema in white male Wistar rat (Rattus norvegicus) induced by carrageenan 1%

Inhibitory Activity of Distilled water and Ethanol Extracts of Moringa oleifera Leaves Against Enterobacter aerogenes

Identifikasi Senyawa Kimia Dan Nilai Gizi Ekstrak Air Daun Kelor (Moringa Oleifera L.) Sebagai Pengawet Alami Mie Basah

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