Pengaruh Pemberian Kacang Hijau (Phaseolus radiatus L.) terhadap Pencegahan Peningkatan Kadar Glukosa Darah pada Tikus (Rattus novergicus) Galur Wistar Bunting

Abstract

Selama kehamilan terjadi peningkatan kadar glukosa darah seiring bertambahnya usia kehamilan. Pilihan sumber karbohidrat yang tepat diperlukan agar kadar glukosa darah terkontrol selama kehamilan, sehingga dapat mencegah terjadinya diabetes melitus gestasional. Kacang hijau mengandung serat larut tinggi dan memiliki indeks glikemik rendah. Kandungan tersebut dapat mengurangi penyerapan karbohidrat dalam tubuh, sehingga dapat menurunkan kadar glukosa darah. Tujuan penelitian ini untuk mengetahui pengaruh pemberian kacang hijau terhadap pencegahan peningkatan kadar glukosa darah pada tikus putih Wistar yang bunting. Penelitian ini bersifat true experimental in vivo dengan rancangan post test only with control group design. Sampel yang digunakan adalah tikus Wistar usia 2-3 bulan yang bunting. Tikus dibagi dalam empat kelompok yaitu kelompok normal tidak diberi kacang hijau (P0), perlakuan 1 diberi kacang hijau 0,3 g/hari (P1), perlakuan 2 diberi kacang hijau 0,6 g/hari (P2), dan perlakuan 3 diberi kacang hijau 1,2 g/hari (P3). Diketahui bahwa kacang hijau mampu mencegah peningkatan kadar glukosa darah pada tikus Wistar bunting, meski tidak signifikan (p = 0,494). Dosis efektif kacang hijau adalah 0,6 g/ekor/hariyang mampu mengontrol kadar glukosa darah sebesar 88,60 + 8,17 mg/dl. Kata kunci: Glukosa darah, Kacang hijau, Kehamilan.

Levels of Blood Glucose in Animals Try Wistar White Mix (Rattus Norvegicus) Dined by Green Beans of Sari Bean Packaging

“…The mean results of examination of blood glucose levels in white rats before being given treatment were 85 mg / dl and the mean results of examination of blood glucose levels in white rats after being treated were 75 mg / dl which showed a decrease in blood glucose levels of 10 mg / dl. This research is reinforced by previous studies conducted by (Briliansari et al 2016) about the effect of giving green beans (P. radiatus L) to the prevention of increased blood glucose levels in rats (R. novergicus) pregnant wistar strains. Based on research conducted by giving green beans (P. radiatus L) was able to prevent an increase in blood glucose levels in white wistar (R. novergicus) strain of white rats.…”

“…Based on research conducted by giving green beans (P. radiatus L) was able to prevent an increase in blood glucose levels in white wistar (R. novergicus) strain of white rats. (Briliansari et al 2016).…”

“…Green beans have been known to be good for health. Mung beans have a high fiber content of around 7.6 g / 100 g. (Briliansari et al, 2016). Fiber is considered to have a hypoglycemic effect because it influences the increase in insulin secretion and the use of glucose by liver cells, thus reducing blood sugar levels (Iqal et al, 2015).…”

“…Foods with a low glycemic index can improve blood glucose response and eating foods that have a low glycemic index value help reduce blood glucose levels slowly so that it will help control blood glucose levels in the body (Briliansari et al, 2016). The content of green beans consists of compounds of flavonoids, alkaloids, terpenoids and polyphenols (Aruna et al, 2012).…”

“…The results of the study by Kartika Mariyona (2017) showed that the administration of green bean juice (P. radiatus L) affected the increase in hemoglobin levels and also influenced the increase in serum ferritin in adolescent girls with anemia in young women with anemia (Mariyona, 2017). Subsequent research conducted by Briliansari et al (2016) showed that administration of green beans (P. radiatus L) was able to prevent an increase in blood glucose levels in pregnant Wistar (R. novergicus) strain of white rats. So the provision of green beans in the form of packaged drinks to reduce blood glucose levels is unknown, it is necessary to do research on the effect of green bean juice drinks (P. radiatus L) on packaging to decrease blood glucose levels in experimental rats (R. norvegicus) wistar strain .…”