Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Roziana, Roziana; Subagio, Hertanto Wahyu; Suhartono, Suhartono; Widyastiti, Nyoman Suci

doi:10.14710/jgi.3.2.73-79

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Vitamin E supplementation can also increase the levels of endogenous vitamin E which are deficient due to ROS exposure, 27 so that the antioxidant activity produced by vitamin E is not reduced and is able to increase the activity of SOD. 28 In this study, the ability of tender coconut water to increase SOD levels in rats exposed to cigarette smoke was relatively similar to the ability of vitamin E. These results were seen from the average SOD levels in the K3 group (72.5 ± 3.80%) which were relatively similar to SOD levels in group K4 (69.9 ± 6.22U/ml) (p>0.05). Thus, tender coconut water can be used to replace vitamin E supplementation as an antioxidant.…”

Section: Discussionsupporting

confidence: 69%

Tender Coconut Water (Cocos nucifera L.) Can Increase Antioxidant Enzymes and Decrease MDA Levels: Experimental Study on Cigarette Smoke-Exposed Rats

Zulaikhah¹,

Aini²,

Rini³

et al. 2022

Pharmacogn J.

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Background: Cigarette smoke exposure increase free radicals in the body in the form of Reactive Oxygen Species (ROS). Excessive levels of ROS can cause an imbalance between the amount of oxidants and antioxidants that trigger oxidative stress. The state of oxidative stress can be seen from the decrease in antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and increased levels of malondialdehyde (MDA). Tender coconut water contains a variety of substances that are beneficial to the body, including L-arginine and Vitamin C which can increase antioxidant enzymes and reduce oxidative stress. Aim and Objectives: This study aims to determine the effect of giving tender coconut water on increasing antioxidant enzymes such as SOD and CAT and decreasing MDA in rats exposed to cigarette smoke. Material and Methods: Experimental research by Post-Test Only Control Group Design study used 24 rats divided into 4 groups, K1 was the control, K2 was the negative control exposed to cigarette smoke, K3 the positive control was given vitamin E and K4 the treatment group. Furthermore, sampling was continued by examining the levels of SOD and CAT using ELISA (Enzyme-Linked Immunosorbent Assay), while MDA using spectrophotometry. The SOD, CAT, and MDA data were processed using SPSS with the One Way Anova. Results: The administration of tender coconut water at a dose of 8mL/200grBW/day and vitamin E at a dose of 1.8 mg/200gBW/day for 14 days increasing SOD levels, CAT levels and reduce MDA levels. Conclusion: It can be concluded that tender coconut water can increase antioxidant enzymes and reduce MDA in rats exposed to cigarette smoke.

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Section: Discussionsupporting

confidence: 69%

Tender Coconut Water (Cocos nucifera L.) Can Increase Antioxidant Enzymes and Decrease MDA Levels: Experimental Study on Cigarette Smoke-Exposed Rats

Zulaikhah¹,

Aini²,

Rini³

et al. 2022

Pharmacogn J.

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“…Whereas doses of 50mg/kgBW and 200mg/kgBW have not caused any improvement effect. Vitamin E dose of 50mg/kgBW has not been able to ward off the toxicity of strong mercury chloride due to oxidative stress factors where the capacity of vitamin E is still unable to neutralize the presence of mercury chloride due to the higher intensity of mercury chloride (14). While the dose of 200mg/kg does not cause an optimal repair effect because vitamin E has a prooxidant effect (15).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin E Administration on Histopathological Description of Mice (Mus musculus) Liver ExposedÂ toÂ Mercuric Chloride

Charisma¹,

Arianing

2020

JKB

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<p>Mercuric chloride may deposit in the liver with a high metabolic rate, delivering substrate and energy from one metabolic system to others, and processing and synthesizing various substances transported to the body. This research aimed to determine the effect of vitamin E administration on liver histopathology of mice (Mus musculus) exposed to mercuric chloride and to determine the histopathological image of the liver. Samples were grouped into P0 (not treated), P1 (mercuric chloride 50 mg/kgBW), P2 (mercuric chloride 50mg/kgBW + vitamin E 50mg/kgBW), P3 (mercuric chloride 50mg/kgBW + vitamin E 100mg/kgBW), and P4 (mercuric chloride 50mg/kgBW + vitamin E 150mg/kgBW) using experiment laboratory method. The data were analyzed using the One Way ANOVA to recognize the difference in changes in vitamin E on hepatocytes damage exposed to mercury chloride. The results showed mercury chloride damages hepatocyte, while the administration of vitamin E as a whole showed changes in hepatocyte repair. The optimal dose for hepatocyte repair is 100mg/kgBW. </p>

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Pengaruh suplementasi vitamin e (α-tokoferol) terhadap kadar gamma glutamil transferase (ggt) dan kadar nitric oxide (no) pada tikus (Studi pada tikus rattus novergicus strain wistar jantan terpapar inhalasi uap benzene)

Abstract: Background

Cited by 2 publications

References 25 publications

Tender Coconut Water (Cocos nucifera L.) Can Increase Antioxidant Enzymes and Decrease MDA Levels: Experimental Study on Cigarette Smoke-Exposed Rats

Tender Coconut Water (Cocos nucifera L.) Can Increase Antioxidant Enzymes and Decrease MDA Levels: Experimental Study on Cigarette Smoke-Exposed Rats

The Effect of Vitamin E Administration on Histopathological Description of Mice (Mus musculus) Liver ExposedÂ toÂ Mercuric Chloride

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