Vocational High School (VHS) is the initial level of vocational education whose task is to prepare students to become skilled labor in the industrial field. At this time there have been many changes, related to the era of industrial revolution 4.0, and the demands of life in the 21st century. Therefore it is necessary to increase the competence of vocational students in order to respond to these changes, both related to the era of industrial revolution 4.0, and demands for skills 4C to be able to live in existence in the 21st century. How far has the implementation of Vocational Schools been able to respond to these changes and demands? To answer this question, a research is needed entitled "Readiness of Vocational students in order to face the industrial revolution 4.0 and the demands of 21st century skills". Through literature studies, it was found that it was needed: (1) the use of learning models such as Problem Based Learning (PBL), Project Based Learning (PjBL), Cooperative Learning and the like, in order to foster 4C skills capabilities for vocational students; (2) the use of learning media such as e-larning, Flipped classroom and podcasts; (3) IoT utilization, digital literacy, and utilization of e-books that are cheap, practical, environmentally friendly, and up to date, (2) improving teacher quality related to the demands of 21st century skills.
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