This research was purposed to find out the effect of Blended Learning based on Edmodo Application to the college students' learning outcome. It was done as a part of small group test phase on the research and development of macroeconomics teaching material at Economics Faculty of Universitas Negeri Medan. This research was applied in experimental research design. The populations of this research are the third semester students of Macroeconomics Theory subject at Economics Education Study Program that consisted of three classes. The samples of this research are the students of C class as many as thirty students. The technique of the data analysis was statistic parametric paired sample t-test approach by testing the normality assumption and homogeneity of the previous data. Validation instrument is using expert judgment. Based on the result of this research, it can be concluded that there was significant different of students' learning outcome before and after the treatment of Blended Learning based on Edmodo Application at Macroeconomics Theory subject at significant level alpha 5%. The mean score of the post test was (75,5) higher compared to the mean score of the pre-test (35,5). Generally, the treatment of Blended Learning based on Edmodo Application to the students' learning outcome at Macroeconomics Theory subject gave effect at the middle category with N-gain score 0,62 (0,3 ≤ g ≤ 0,7). In order to improve the efficiency of Blended Learning, it was suggested to previously observe the students' learning aid, the ability of the teachers in designing content and the Blended Learning system mastery, and also in observing the students' satisfactory aspects.