Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae

Abstract

Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2–6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL.

New Indole Diketopiperazine Alkaloids from Soft Coral‐Associated Epiphytic Fungus Aspergillus sp. EGF 15‐0‐3

“…Additionally, the configuration of the C‐8/C‐9 double bond and C‐12 were shown to be ( R ) and ( S ), respectively . Clearly, the isopentenylation of the benzene ring or indole ring and the oxidoreduction and sulfuration of diketopiperazine ring resulted in diversities of the structures . Research on the preliminarily cytotoxic activities of compounds and fractions showed that the cytotoxic effects of Fr.…”

Investigation of mycoviruses in endophytic and phytopathogenic strains of Colletotrichum from different hosts

“…against ATCC bacteria had the best result against P. aeruginosa (MIC = 160 µg/mL). Meng et al (2015), isolated and identified five new compounds from the culture extract of Penicillium brocae MA-231, an endophytic fungus isolated from the fresh tissue of the marine mangrove plant Avicennia marina. All of these compounds were examined for antimicrobial activities against S. aureus and Gaeumannomyces graminis.…”

Two new alkaloids from Penicillium oxalicum EN-201, an endophytic fungus derived from the marine mangrove plant Rhizophora stylosa

“…As part of our ongoing research on discovery of secondary metabolites with pharmacologically interesting activities Luo et al, 2014;Meng et al, 2015;Zhang et al, 2014Zhang et al, , 2015, the mangrove-derived endophytic fungus Penicillium oxalicum EN-201, was selected for chemical investigation. The fungal strain was isolated following surface sterilization from the fresh leaves of marine mangrove plant Rhizophora stylosa.…”