Penicillin production by solid state fermentation

Barrios-González, Javier; Tomasini, Araceli; Viniegra‐González, Gustavo; López, Lilibeth Niño

doi:10.1007/bf01027575

Cited by 74 publications

(22 citation statements)

References 7 publications

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“…Furthermore, new applications of SSF have been suggested for the production of antibiotics (Barrios et al, 1988), secondaries metabolites (Trejo-Hernandez et al, 1992 or enriched foodstuffs (Senez et al, 1980). Presently SSF has been applied to large-scale industrial processes mainly in Japan.…”

Section: General Considerationsmentioning

confidence: 99%

General and microbiological aspects of solid substrate fermentation

Raimbault¹

1998

Electron. J. Biotechnol.

375

251

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Section: General Considerationsmentioning

confidence: 99%

General and microbiological aspects of solid substrate fermentation

Raimbault¹

1998

Electron. J. Biotechnol.

375

251

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“…It has been reported that a concentrated medium adequate for SSF, such as 2.5 ! media formulation for submerged culture, is not convenient for secondary metabolites production in SmF [Baños et al, 2009;BarriosGonzález and Tomasini, 1996;Barrios-González et al, 1988]. In order to confirm if this statement applies to A. chrysogenum cultures, a SmF using 2.5 !…”

Section: Resultsmentioning

confidence: 99%

“…The bagasse was pretreated as previously described [Barrios-González et al, 1988], and impregnated to 70% initial moisture content with 2.5 ! concentrated PM with the inoculum.…”

Section: Ssfmentioning

confidence: 99%

“…Solid inoculated medium (12 g) was placed into a 16-cm long and 2.2-cm diameter glass column, at a packing density of 0.26 g/ml. Columns were incubated under nonaseptic conditions, as described previously [Barrios-González et al, 1988] at 25 ° C with a wet air flow rate of 0.45 l/h ؒ g dry matter. Three independent columns were analyzed for each sample point.…”

Section: Ssfmentioning

confidence: 99%

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Solid-State and Submerged Fermentations Show Different Gene Expression Profiles in Cephalosporin C Production by <b><i>Acremonium chrysogenum</i></b>

et al. 2012

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Despite the importance of Acremonium chrysogenum as the only cephalosporin C (CPC) producer, there is still a limited understanding about the molecular mechanisms regulating antibiotic biosynthesis in this fungus. Based on the previously described relationship between environmental pH and antibiotic production in numerous filamentous fungi, we studied the expression of genes related to CPC production in A. chrysogenum. We report for the first time similarities and differences, characterizing CPC production by A. chrysogenum under a variable pH environment, in submerged and solid-state fermentation. This characterization is supported by measurements of parameters, like CPC production, pH, growth, and expression levels of several genes involved, directly or indirectly, in CPC production. Interesting differences in intermediate (Pen N) and certain biosynthetic gene expression levels were observed. Our results point out some relationships between physiological features and gene expression that open important improvement perspectives for both culture systems.

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“…However, it has been shown (for lovastatin, penicillin and other SM) that good performance in these SSF systems requires the use of a more concentrated liquid medium (between 2 and 2·5x) (Barrios‐González et al . ; Cuadra et al . ; Baños et al .…”

Section: Introductionmentioning

confidence: 99%