Penicilloyl-polylysine intradermal testing for penicillin hypersensitivity.

Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

“…Allergic reactions to penicillin also constitute a significant problem. Lentz and Nicholas found that 7.7%0 of 5,461 patients reporting to a large venereal disease clinic in Philadelphia were hypersensitive to penicillin as indicated by a positive skin reaction when tested with penicilloyl-polylysine (5). The foregoing factors make it imperative that new therapeutic agents be continually developed and evaluated in the treatment of gonorrhea.…”