Penile Intraepithelial Neoplasia and Other Premalignant Lesions of the Penis

Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated penile intraepithelial neoplasia in nonendemic regions for penile cancer when compared with endemic areas: a comparative study between pathologic series from Paris and Paraguay

“…This is not a population-based study nor was it designed to evaluate demographic and epidemiological features of patients with penile cancer. Nevertheless, our findings are in agreement with series reporting a higher frequency of HPV-related premalignant lesions in countries with a low incidence of penile cancer and higher incidence of HPV-unrelated lesions in geographic regions with high ASR [3,5,16,17]. Moreover, this is the first study deliberately comparing penile precancerous lesions in a rather large series of cases from geographic areas with disparate incidence rates of penile cancer.…”

“…Considering the similarities in the etiopathogenesis and morphology of penile and vulvar precancerous and invasive lesions [6,[27][28][29], a similar trend can be expected in the future for penile lesions. Finally, inasmuch as that some HPV-related penile lesions may present spontaneous regression [16,17,30,31], this phenomenon might also explain, at least in part, the differences between the higher rate of HPV detection in precursor lesions when compared with invasive carcinomas, but it does not account for the geographic differences we found. Mechanisms by which spontaneous regression of HPV-related lesions occur are poorly understood, and there is no apparent reason for a significant difference in the spontaneous regression rate depending on the geographic region in consideration.…”

Increased incidence of penile cancer and high-grade penile intraepithelial neoplasia in Denmark 1978–2008: a nationwide population-based study

“…The median age at diagnosis for high-grade PIN (56 years) was not reported in these studies. However, a review by Crispen et al [7] reported a mean onset of PIN3 lesions of 56.1 years. In the present study, more than half of the penile cancers were diagnosed in a localized stage (55.0%), and fewer were diagnosed with regional spread (12.2%) or distant metastases (2.7%).…”

“…The overall five-year survival rate of the cancer is around 70% [6]. Penile intraepithelial neoplasia (PIN) is a precursor lesion of penile cancer and encompasses the spectrum from mild dysplasia (PINI) to severe dysplasia (PIN3) including carcinoma in situ (CIS) [7].…”

Erythroplasia of Queyrat

“…It is considered as a minimally invasive treatment able to offer good results as reported in two cases (Sonnex et al 1982 ), but the selection of this type of treatment should be individually considered, and a close follow-up has to be ensued. Other authors do not recommend cryosurgery because of the lack of consistent depth of treatment (Crispen and Mydlo 2010 ).…”