“…Antibiotics are defined as the result of production in the form of chemicals, where these materials can interfere with other microorganisms such as bacteria and fungi (Kaye, Petty, Shorr, & Zilberberg, 2019). Multiple osteonecrosis can be treated with prophylaxis or reconstructive surgery in other words, this therapy is to slow the progression of osteonecrosis by endoprosthetic replacement of the affected bone & soft tissue (Rahayu, Masfiyah, Puspitasari, & Sari, 2016). The most frequently used prophylactic surgery is core decompression of the femoral head, to prevent venous congestion and to stimulate repair (Nabiu, Anandani, & Hardiansyah, 2021).…”