Pentacyclic Triterpenes from Branches ofMaytenus robustaandin vitroCytotoxic Property Against 4T1 Cancer Cells

Anticancer Activity of 2-O-caffeoyl Alphitolic Acid Extracted from the Lichen, Usnea barbata 2017-KL-10

“…The highest concentration (50 μM) exhibited a stronger inhibitory effect than the lower concentrations (12.5 or 25 μM) ( Figure 2 B). This result is consistent with previous studies showing that triterpenoids have cytotoxic properties against various tumor cells such as melanoma, liver cancer, breast cancer, and glioma [ 34 , 35 ]. Subsequently, we observed the morphological features of the 2OCAA-exposed cells under the microscope.…”

“…Recently, there has been a growing interest in natural products as therapeutic agents worldwide. Among them, lupane-type triterpenes such as betulin, betulinic acid, and lupeol have shown multiple biological activities against various cancer cell lines and encouraging antitumor effects [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. In this study, 2OCAA showed concentration-dependent anticancer activities such as cytotoxicity, induction of apoptosis, inhibition of cell migration and invasion of colorectal cancer.…”

Phytochemical and Biological Studies of Natural Egyptian Recipe with Anticancer Effect

“…showed nearly double potency of the reference drug vinblastine sulfate with IC 50 value 30.2 g/ml .While, the methanol extract of recipe showed high potency compared to the reference drug vinblastine sulfate with IC 50 value 70.8 g/ml. These result in agreement with the previously reported by Sousa et al 2014 [12,13] ; that triterpenes show cytotoxic properties against tumor cells, at low activity toward normal cells. Triterpenes are compounds of natural origin, which have numerous biological activities: anticancer properties, antiinflammatory, antioxidant, antiviral, antibacterial and anti-fungal.…”

“…Triterpenes are compounds of natural origin, which have numerous biological activities: anticancer properties, antiinflammatory, antioxidant, antiviral, antibacterial and anti-fungal. Recently, when neoplasms are main cause of death, triterpenes can become an alternative method for treating cancer because of their cytotoxic properties and chemopreventive activities [12,13] .…”

Triterpenes as Potentially Cytotoxic Compounds

“…Euphorbia macrostegia extract contains four cycloartane triterpenoids which possess cytotoxic activity against two human breast cancer lines: MDA-MB48 and MCF-7 [33]. Branches of Maytenus robusta contains seven pentacyclic triterpenes (friedelane-type) presenting cytotoxicity against 4T1 cells (murine breast cancer cells) [34]. Moreover roots of Hemsleya penxianesis contains six cucurbitane triterpenoids with cytotoxic activities against human lung adenocarcinoma cells (H460) and colon cancer cells (SW-620, COLO205) [35].…”