Pentylenetetrazol-induced seizures and kindling: changes in free fatty acids, superoxide dismutase, and glutathione peroxidase activity

Antiepileptic potential of <i>Silybum marianum</i> seeds in pentylenetetrazol-induced kindled mice

“…In corroboration higher lipid peroxidation and lower anti-oxidant enzyme level following pentylenetetrazol induced kindling mice or rat models had been reported Erakovic et al (2003).…”

“…It was concluded from present experiment that pre-treatment with plant extract reduced brain damage caused by oxidative radicals. Erakovic et al (2003) reported higher activity of glutamanergic synapses through N-methyl-D-aspartate (NMDA) receptors, higher glutamate extracellular levels and free radicals by the use of pentylenetetrazol in kinling mice.…”

Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice

“…16 Another mechanism suggested by other studies has demonstrated that oxidative stress might be involved in the pathophysiology of pentylenetetrazole (PTZ) induced epilepsy. [17][18][19][20][21] Pentylenetetrazole (PTZ) at a convulsant dose decreases antioxidant enzymes activity and glutathione levels and increases lipid peroxidation in brain.…”

Ghrelin Regulation in Epilepsy

“…In fact vagal nerve stimulations are associated with a reduction of the seizure frequency more than 50% in about 30% of patients who are refractory to epilepsy treatments (Ben-Menachem et al, 1999;Handforth et al, 1998;Morris & Mueller, 1999). The oxidative stress in the central nervous system in relation to discharges in the epileptic rat brain has been reported in several rodent models of epilepsy (Bruce & Baudry, 1995;Erakovic et al, 2003;Singh & Pathak, 1990;Veerendra Kumar & Gupta, 2003). At this regard, there is emerging evidence that oxidative stress and mitochondrial dysfunctions result as a consequence and a cause of seizures (Patel, 2002).…”