Peptide-based delivery to bone

Aoki, Kazuhiro; Alles, Neil; Soysa, Niroshani Surangika; Ohya, Keiichi

doi:10.1016/j.addr.2012.05.017

Cited by 53 publications

(36 citation statements)

References 195 publications

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“…For instance, the osteoporosis drug Forteo 1 (generic name: teriparatide) must be administered daily via injection and is associated with severe systemic side effects such as headaches, orthostatic hypertension, hypercalcaemia, and potentially tumors (Cipriani et al, 2012). It would be safer and more effective if the drug could be delivered specifically to bone tissue via a controllable, sustained release delivery system (Aoki et al, 2012). Therefore, there exists a strong need for developing a targeted delivery system specific to bone tissue by using a sustained release drug delivery device.…”

Section: Introductionmentioning

confidence: 99%

Poly aspartic acid peptide-linked PLGA based nanoscale particles: Potential for bone-targeting drug delivery applications

Jiang

Carbone

et al. 2014

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Poly aspartic acid peptide-linked PLGA based nanoscale particles: Potential for bone-targeting drug delivery applications

Jiang

Carbone

et al. 2014

International Journal of Pharmaceutics

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“…While injectable systems are more commonly thought of in reference of depot systems, it is also important to consider the role of surgically placed depots as well; drug-loaded polymeric and ceramic scaffolds are an ideal approach to drug delivery to fracture sites and bone surfaces following surgical intervention. Drug loading into supportive structures for continuous release with or without drug carriers provides local chemical treatment as the graft is resorbed, allowing for ensured delivery of therapeutics to the desired site, as demonstrated by Orellana et al using simvastatin and a model protein [96]. Further, certain ceramic materials may act as depots for bioactive molecules without additional loading or modification; silicon, magnesium, and strontium based ceramics release metal ions that promotes osteogenic function and inhibit resorptive behavior [97–99].…”

Section: Drug Delivery Approaches For Osteoporosismentioning

confidence: 99%

Advances in Controlled Drug Delivery for Treatment of Osteoporosis

Asafo-Adjei

Chen

Najarzadeh

et al. 2016

Curr Osteoporos Rep

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Osteoporosis, which is characterized by resorption of bone exceeding formation, remains a significant human health concern, and the impact of this condition will only increase with the “greying” of the worldwide population. This review focuses on current and emerging approaches for delivering therapeutic agents to restore bone remodeling homeostasis. Well-known antiresorptive and anabolic agents such as estrogen, estrogen analogs, bisphosphonates, calcitonin, and parathyroid hormone, along with newer modulators and antibodies, are primarily administered orally, intravenously, or subcutaneously. Although these treatments can be effective, continuing problems include patient non-compliance and adverse systemic or remote-site effects. Controlled drug delivery via polymeric, targeted, and active release systems extends drug half-life by shielding against premature degradation and improves bioavailability, while also providing prolonged, sustained, or intermittent release at therapeutic doses to more effectively treat osteoporosis and associated fracture risk.

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“…In order to have a further improvement on the biological activity and osteogenic ability of materials, researchers have studied the binding of biologically active molecules (including growth factors and peptides) to the surface of biomaterials . Among the biologically active molecules, osteogenesis‐related synthesis of peptide and associated matrixes have a low cost but a strong stability when compared to active proteins with longer amino acid sequences, as a result, peptides are potentially more suitable as bone repair materials . In addition, small peptides are superior to large peptides and proteins for their ability to bind with higher affinities to integrins and resistance to proteolysis .…”

Section: Introductionmentioning

confidence: 99%

Peptide‐modified bone repair materials: Factors influencing osteogenic activity

Liao

et al. 2019

J Biomedical Materials Res

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Many factors have been demonstrated as having an influencing effect on the osteogenic activity of the peptide‐modified bone repair materials. However, most of studies only focus on one or two aspects that result in an incomplete direction for materials preparation, characterization, and performance evaluation. In this review, we reported several factors through summarizing previous research studies, which are mainly centered on three aspects: (1) the characteristics of peptide immobilized on the surface of matrix (e.g., type and length of sequence, structure, and density); (2) the combination mode between peptide and matrix (including covalent binding in selective or nonselective immobilization, and noncovalent binding through simple absorption or mixing with the matrix, and other factors in covalent binding); and (3) the properties of the matrix (including surface structure and morphology, dimension, mechanical properties, hydrophobic–hydrophilic balance, adsorbing proteins on materials), and the other possible influencing factors such as binding to other peptides. In addition, attentions were paid to the introduction and the discussion of newest studies and the analysis of mechanism. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Peptide-based delivery to bone

Cited by 53 publications

References 195 publications

Poly aspartic acid peptide-linked PLGA based nanoscale particles: Potential for bone-targeting drug delivery applications

Poly aspartic acid peptide-linked PLGA based nanoscale particles: Potential for bone-targeting drug delivery applications

Advances in Controlled Drug Delivery for Treatment of Osteoporosis

Peptide‐modified bone repair materials: Factors influencing osteogenic activity

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