Peptide‐modified bone repair materials: Factors influencing osteogenic activity

Abstract

Many factors have been demonstrated as having an influencing effect on the osteogenic activity of the peptide‐modified bone repair materials. However, most of studies only focus on one or two aspects that result in an incomplete direction for materials preparation, characterization, and performance evaluation. In this review, we reported several factors through summarizing previous research studies, which are mainly centered on three aspects: (1) the characteristics of peptide immobilized on the surface of matrix (e.g., type and length of sequence, structure, and density); (2) the combination mode between peptide and matrix (including covalent binding in selective or nonselective immobilization, and noncovalent binding through simple absorption or mixing with the matrix, and other factors in covalent binding); and (3) the properties of the matrix (including surface structure and morphology, dimension, mechanical properties, hydrophobic–hydrophilic balance, adsorbing proteins on materials), and the other possible influencing factors such as binding to other peptides. In addition, attentions were paid to the introduction and the discussion of newest studies and the analysis of mechanism. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

Chimeric Peptides Quickly Modify the Surface of Personalized 3D Printing Titanium Implants to Promote Osseointegration

“…Cell migration and proliferation of chimeric peptide-modified Ti groups are better than those of the 3D-Ti group (Figure ), indicating that chimeric peptide-modified Ti surfaces have good biocompatibility and non-cytotoxicity. Moreover, it has been reported that peptide sequences affected cellular responses . Accordingly, the proliferation and migration of the cells with linker groups are better than those without linker groups (S-P1&2-Ti group vs S-P3&4-Ti group; L-P1&2-Ti group vs L-P3&4-Ti group), which illustrates that the addition of linker (GP) 4 might maintain the distance between different peptides, thereby improving the bio-functions of chimeric peptide-modified Ti surfaces.…”

“…In addition, Otsuki et al found that W9 treatment further significantly upregulated ColI and RUNX2 genes expression in hAdSCs compared to those with BMP2 treatment . To our knowledge, the immobilization of peptides on the Ti surfaces through covalent and non-covalent binding has a series of disadvantages, such as the complicated processing process, the toxicity of the coupling agent, and the inactivation of active groups due to hydrolysis . Hence, a rapid and effective strategy to coat Ti implant surfaces with functional peptides (W9 and PR1P) is required in urgent.…”

Fabrication and Application of Novel Porous Scaffold in Situ-Loaded Graphene Oxide and Osteogenic Peptide by Cryogenic 3D Printing for Repairing Critical-Sized Bone Defect

“…Generally, the rapid release and degradation of osteoinductive drugs compromise their function. Therefore, the development of a smart delivery system that allows the drug to be released sustainably is necessary for the optimization of osteoinductive drugs [9].…”

Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide

“…Therefore, the modulation of the osteogenic properties of these cells represents a potential target to promote soft tissue attachment to bone. Bergemann et al, (2015) have demonstrated the influence of implant material surface topography on the behavior of primary human osteoblasts [13]. This investigation demonstrated that in vitro, micro-structured zirconia surfaces can modulate key bone-related gene expression in human primary osteoblasts, enhancing osseointegration of oral implants.…”