Peptide Modified Albumin–Paclitaxel Nanoparticles for Improving Chemotherapy and Preventing Metastasis

Abstract

Metastasis and recurrence are the main causes of death in cancer patients; however, there are few medicines that can inhibit tumor growth and metastasis at the same time. In this work, a novel nano-drug delivery system (NDDS) based on targeting ligand modified albumin is reported. The hydrophobic drug (paclitaxel) induces albumin self-assembly after treatment of albumin with l-cysteine, forming drug-loaded nanoparticles with a size of 100-200 nm. Importantly, the albumin nanoparticles display enhanced antitumor efficacy against tumor growth/lung metastasis in 4T1 bearing nude mice and prevention of lung metastasis in a B16-F10 model. This study provides a facile method for hydrophobic chemo-drugs loaded albumin nanoparticles preparation and a promising chemotherapy with effective tumor growth inhibition and metastasis prevention.

Circular Dichroism as a Rapid Method for Analyzing the Binding of a Targeting Ligand to the Surface of Albumin Nanoparticles

“…Human serum albumin (HSA) as well as bovine serum albumin (BSA) are characterized by biocompatibility, biodegradability and low immunogenicity [2]. There are many potential binding sites on the albumin molecule, which creates the possibility to interact with a variety of chemicals, including drugs, crosslinking factors and targeting ligands [2,3].…”

Effect and mechanism of paclitaxel loaded on magnetic Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites to MCF-7 cells

“…The synthesis of precursor drugs is a complicated and expensive process, and their pharmacodynamics and pharmacokinetic properties may change unexpectedly. Regarding PTX preparation, nanoparticles have the advantages of high drug loading, large specific surface area, significantly increasing water solubility and reduced toxic and side effects (Fu et al., 2022 ; Gulsu et al., 2022 ; Sakhi et al., 2022 ). Magnetic nanodrug delivery systems have attracted increasing attention because of their good biocompatibility and multifunctional carrying capacity.…”