Peptides, new tools for plant protection in eco-agriculture

Zhang, Yimeng; Ye, De-Xing; Liu, Yan; Zhang, Mengjie; Zhou, Yubin; Zhang, Li; Yang, Xinling

doi:10.1016/j.aac.2023.01.003

Cited by 47 publications

(33 citation statements)

References 307 publications

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“…59 The development of peptide-based agrochemicals with high efficiency, low cost, and environmental safety has become a global trend. 60 In our study, we discovered that SpPIP1 can rapidly activate plant immunity, leading to increased expression of SlPR1 and SlPR3 through SAR and ISR pathways. This indicates that SpPIP1 holds the potential to function as an alternative to chemical plant activators.…”

Section: ■ Discussionmentioning

confidence: 74%

“…(ISR activator), have proven effective in controlling diseases in crops like tomato and strawberry . The development of peptide-based agrochemicals with high efficiency, low cost, and environmental safety has become a global trend . In our study, we discovered that SpPIP1 can rapidly activate plant immunity, leading to increased expression of SlPR1 and SlPR3 through SAR and ISR pathways.…”

Section: Discussionmentioning

confidence: 82%

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Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Yang

Wang

Zhao

et al. 2023

J. Agric. Food Chem.

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Tomato is a globally important horticultural and economic crop, but its productivity is severely affected by various stresses. Plant small secretory peptides have been identified as crucial mediators in plant resistance. Here, we conducted a comparative transcriptome analysis and identified the prePIP1 gene from Solanum pimpinellifolium (SpprePIP1), as an ortholog of Arabidopsis prePIP1 encoding the precursor protein of PAMP-induced SSP 1. The expression level of SpprePIP1 is transcriptionally induced in tomato upon infection with Phytophthora infestans (P. infestans), the pathogen responsible for late blight. Overexpression of SpprePIP1 resulted in enhanced tomato resistance to P. infestans. In addition, exogenous application of SpPIP1, whether through spraying or irrigation, improved tomato resistance by enhancing the transcript accumulations of pathogenesis-related proteins, as well as reactive oxygen species and the jasmonic acid (JA) levels. Integrated analysis of transcriptomics and metabolomics revealed the potential contributions of JA and phenylpropanoid biosynthesis to SpPIP1-induced tomato immunity. Additionally, SpPIP1 may strengthen tomato resistance to salt stress through the ABA signaling pathway. Overall, our findings demonstrate that SpPIP1 positively regulates tomato tolerance to P. infestans and salt stress, making it a potential plant elicitor for crop protection in an environmentally friendly way.

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Section: ■ Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 82%

Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Yang

Wang

Zhao

et al. 2023

J. Agric. Food Chem.

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“…One of the most promising compounds is probably peptides, which are able to fight insects as well as fungal and bacterial attacks [ 6 , 7 , 8 ]. Investigating entomotoxic peptides within plants, particularly those consumed by mammals, can be a beneficial approach to develop sustainable and secure biopesticides for agriculture [ 8 , 9 ].One of the most promising of these compounds is the Albumin 1, subunit b peptide, extracted from leguminous plants. Legumes (Fabaceae) are important economic crops that provide food for humans, feed for livestock and raw materials for industry [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Residues of Legume AG41 Peptide Crucial to Its Bio-Insecticidal Activity

et al. 2023

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Currently, crop protection relies heavily on chemical treatments, which ultimately leads to environmental contamination and pest resistance. Societal and public policy considerations urge the need for new eco-friendly solutions. In this perspective, biopesticides are effective alternatives to chemical insecticides for the control of various insect pests. Legumes contain numerous insecticidal proteins aimed at protecting their high nitrogen content from animal/insect predation. Investigating one such protein family at genome scale, we discovered a unique diversity of the albumin 1 family in the (model) barrel medic genome. Only some members retained very high insecticidal activity. We uncovered that AG41 peptide from the alfalfa roots displays an outstanding insecticidal activity against several pests such as aphids and weevils. Here we report the 3D structure and activity of AG41 peptide. Significant insights into the structural/functional relationships explained AG41 high insecticidal activity. Such observations pave the way for the development of bio-insecticides, with AG41 peptide as the lead compound.

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“…11,12 In 2016, the global sales of SDH inhibitory fungicides were $1.691 billion, which accounted for 3.0% of the $56.452 billion global pesticide market. 13 In 2019, the market value of SDH inhibitory fungicides was $2.311 billion, which accounted for 12.7% of the global pesticide market. The increased market share of SDH inhibitory fungicides could, in turn, stimulate research investigations into SDH inhibitory fungicides.…”

Section: ■ Introductionmentioning

confidence: 99%

Discovery of Benzothiazolylpyrazole-4-Carboxamides as Potent Succinate Dehydrogenase Inhibitors through Active Fragment Exchange and Link Approach

Yin,

Sun,

Wang

et al. 2023

J. Agric. Food Chem.

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Succinate dehydrogenase (SDH) is an attractive target for developing green fungicides to manage agricultural pathogens in modern agriculture research. Herein, in this work, we report the discovery of benzothiazolylpyrazole-4-carboxamides I-III as potent SDH inhibitors using active fragment exchange and link approach. The results of the fungicidal activity assays showed that some of the synthesized compounds exhibited excellent inhibition against the tested fungi. Systematic structure−activity relationship studies led to the discovery of compound Ip, N- (1-((4,6-difluorobenzo[d]thiazol-2-yl)thio)propan-2-yl)-3-(difluoromethyl)-N-methoxy-1-methyl-1H-pyrazole-4-carboxamide, which showed higher fungicidal activity against Fusarium graminearum Schw (EC 50 = 0.93 μg/mL) than the commercial fungicides thifluzamide (EC 50 > 50 μg/mL) and boscalid (EC 50 > 50 μg/mL). The molecular simulation studies suggested that hydrophobic interactions were the primary driving forces between ligands and SDH. Promisingly, we found that Ip could stimulate the growth of wheat seedlings and Arabidopsis thaliana and increase the biomass of the treated plants. Preliminary studies on the plant growth promoter mechanism of Ip indicated that it could increase nitrate reductase activity in planta, that, in turn, stimulates the growth of plants.

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Peptides, new tools for plant protection in eco-agriculture

Cited by 47 publications

References 307 publications

Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Residues of Legume AG41 Peptide Crucial to Its Bio-Insecticidal Activity

Discovery of Benzothiazolylpyrazole-4-Carboxamides as Potent Succinate Dehydrogenase Inhibitors through Active Fragment Exchange and Link Approach

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