Patient adherence during the treatment period must be considered, because patient adherence plays an important role in achieving therapeutic success, especially for chronic diseases. Treatment non-adherence is a common and complex problem. Failure to follow a treatment schedule can lead to major health complications, including death. To avoid it, several interventions are needed to control patient non-adherence. There are several interventions that can support and improve patient adherence. These include digital interventions; increasing patient knowledge and understanding of the treatment being undertaken with counseling, Drug Information Services (PIO), providing educational leaflets, digital pillbox reminders and Pill Cards; family support; diaries; keep treatment commitments. Based on this, it is necessary to have an intervention method in terms of education (educational), behavior (behavior), and attitude (affective) in order to achieve patient adherence and the success of chronic disease therapy.