PERBEDAAN DAYA HAMBAT OBAT ANESTESI LOKAL LIDOCAINE 2% DAN ARTICAINE 4% TERHADAP PERTUMBUHAN BAKTERI Porphyromonas gingivalis SECARA IN VITRO

Abstract

Porphyromonas gingivalis is a gram-negative anaerobic bacteria which is an oral normal microflora located in subgingival area.This bacteria can cause inflamation and delayed wound healing after dental invasive procedures. Lidocaine 2% and articaine 4% are the most used anaesthetic agents in dentistry. Both of these agents have been studied for having antibacterial effect in certain concentrations. This will open the possibility of using local anaesthetic agents as antibacterial agent in dental invasive procedures to prevent infection after procedures. The purpose of this study is to analyze the difference inhibition of local anaesthetics drug lidocaine 2% and articaine 4% on the growth of Porphyromonas gingivalis bacteria in vitro. The study subject was pure culture of Porphyromonas gingivalis ATCC 33277 divided by two group, one group with lidocaine 2% and other with articaine 4%. This study was experimental laboratory with post test only control group design. The mean of inhibitions were obtained by measuring inhibition zone formed around paper discs with caliper in milimeter scale. The result showed Inhibition rate lidocaine 2% had greater rate than articaine 4% in inhibiting the growth of Porphyromonas gingivalis bacteria in vitro.The conclusion was lidocaine 2% was more effective than articaine 4% in inhibiting the growth of Porphyromonas gingivalis bacteria in vitro.
 Keywords: Antibacteria, Local anaesthetic, Lidocaine 2%, Articaine 4%, Porphyromonas gingivalis

Concentration Effect of Leaf Extract from Kekara Laut (Canavalia Maritima Thou.) in inhibiting of Staphylococcus Epidermidis Bacteria with a Statistical Science Approach

“…However, the closure of the diameter zone of the 20% w/v is relevanted with 15% w/v. According to Muharammy et al (2016) that the ability inhibitory zone of the compound as an antibacterial is shown that the 15-20 mm range is categorized in moderate hamps. While the inhibitory diameter zone more than 20 mm shows the power of stronger.…”

Uji Perbandingan Efektivitas Kerja Anestetikum Lidokain dan Lidokain + Epinefrin Terhadap Rasa Nyeri

“…Bahan anestesi lokal terbagi atas dua golongan yaitu ester dan amida. (6,7,8,9) Anatesi lokal adalah cara yang paling aman dan paling efektif dalam manajemen nyeri bahan anestesi lokal dapat menghilangkan rasa sakit yang timbul akibat prosedur kedokteran gigi yang dilakukan. Anastesi lokal memblok saraf perifer yang kemudian mencegah rasa sakit, selama dan setelah prosedur bedah.…”

“…Pada bidang kedokteran gigi lidokain sering ditambahkan adrenalin, adrenalin ini berfungsi sebagai vasokonstriktor yang dapat mempercepat mula kerja obat, meningkatkan lama kerja larutan anestesi lokal, menurunkan konsentrasi puncak larutan, anestesi di dalam darah sehingga toksisitas obat berkurang, memperkecil volume pemakaian larutan anestesi lokal, meningkatkan kedalaman efek anestesi lokal dan meningkatkan efektivitas larutan anestesi lokal. (10,12,9) Berdasarkan latar belakang di atas, peneliti tertarik untuk meneliti perbandingan efektivitas kerja anestetikum lidokain dan lidokain + epinefrin terhadap rasa nyeri pada pasien di RSIGM UMI sehingga dapat dijadikan pertimbangan dan dapat digunakan sebagai panduan penelitian selanjutnya.…”

“…Persentase dokter gigi menggunakan bahan ini yaitu 41,93%, menjadikan lidocain HCl 2% sebagai bahan anastesi yang paling sering digunakan dalam tindakan ekstraksi gigi. Hal ini disebabkan onsetnya yang lebih cepat, lebih stabil, serta tingkat toksisitas dan alergenik yang rendah dan dibandingkan bahan anastesi lainnya (9) .…”