The current paper investigates the factors, i.e., environmental, business, behavioral, and human relations, that promote entrepreneurial sustainability of SMEs in Pakistan. The study employs the quantitative approach, which utilizes the cross-sectional data of 347 entrepreneurs of the SMEs sector of Pakistan. The data study applies a survey questionnaire to collect the data. The random technique is employed to target the respondents. By employing the structural equation model (SEM), the study finds a positive and significant impact of environment/surroundings, business, behavior, and human-related factors on entrepreneurial sustainability. In a simple sense, all the hypotheses are accepted. The study’s findings would encourage practitioners, researchers, and policymakers to hunt the patterns of social, behavioral, economic, human, and environmental contributions to promote entrepreneurial activity. Further, the study would provide an optimal solution to utilize these factors for bringing sustainable development SMEs.