Percutaneous absorption and skin erythema: Quantification of capsaicin and its synthetic derivatives from gels incorporated with benzalkonium chloride by using non-invasive bioengineering methods

Fang, Jia‐You; Tsai, Ming-Jun; Huang, Yaw‐Bin; Wu, Pao‐Chu; Tsai, Yi‐Hung

doi:10.1002/(sici)1098-2299(199701)40:1<56::aid-ddr6>3.0.co;2-s

Cited by 21 publications

(11 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TEWL refers to the rate at which water migrates from the viable tissues through the layer of the SC to the external environment. This method has been performed to assess skin damage, demonstrating a good correlation between damage of skin barrier and increase in TEWL 23. Typical basal values of TEWL in nude mouse were 29.1 ± 4.8 g/m 2 /h (Table 3).…”

Section: Resultsmentioning

confidence: 91%

The Effect of Laser Treatment on Skin to Enhance and Control Transdermal Delivery of 5‐Fluorouracil

Lee

Shen

Wang

et al. 2002

Journal of Pharmaceutical Sciences

112

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 91%

The Effect of Laser Treatment on Skin to Enhance and Control Transdermal Delivery of 5‐Fluorouracil

Lee

Shen

Wang

et al. 2002

Journal of Pharmaceutical Sciences

112

View full text Add to dashboard Cite

“…Although its transdermal flux was determined to be the least of the three drugs tested, sodium nonivamide is more potent than capsaicin in its pharmacological action. Nonivamide was also found to be less irritating than capsaicin in this study while displaying similar flux to capsaicin as well [87]. …”

Section: Challenges and Solutions For Overcoming Skin Irritationmentioning

confidence: 83%

Challenges and Opportunities in dermal/transdermal Delivery

Paudel

Milewski

Swadley

et al. 2010

Therapeutic Delivery

500

264

View full text Add to dashboard Cite

Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.Delivery of drugs through the skin has been an attractive as well as a challenging area for research. Advances in modern technologies are resulting in a larger number of drugs being delivered transdermally including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Transdermal systems are a desirable form of drug delivery because of the obvious advantages over other routes of delivery. Transdermal delivery provides convenient and pain-free self-administration for patients. It eliminates frequent dosing administration and plasma level peaks and valleys associated with oral dosing and injections to maintain a constant drug concentration, and a drug with a short halflife can be delivered easily. All this leads to enhanced patient compliance, especially when long-term treatment is required, as in chronic pain treatment and smoking cessation therapy. Avoidance of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs is another advantage of transdermal delivery. Elimination of this first-pass effect allows the amount of drug administered to be lower, and hence safer in hepato-compromised patients, resulting in the reduction of adverse effects. Transdermal systems are generally inexpensive when compared with other therapies on a monthly cost basis, as patches are designed to deliver drugs from 1 to 7 days. The other advantage of transdermal delivery is that multiple dosing, on-demand or variable-rate delivery of drugs, is possible with the latest programmable systems, adding more benefits to the conventional patch dosage forms. The general acceptability of transdermal products by patients is very high, which is also evident from the increasing market for transdermal products. The transdermal drug delivery market, worth $12.7 billion dollars in 2005, is expected to reach $32 billion in 2015 [1].

show abstract

“…The luminance (L*) gives the relative brightness from black to white. The a* represents the balance between red and green and the b* represents the balance between yellow and blue (Fang et al 1997). The total difference of skin colour can be expressed as ÁE*, ÁE* ¼ ((ÁL*) 2 þ (Áa*) 2 þ (Áb*) 2 ) 1/2 .…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of the essential oil from Magnolia fargesii for enhancing the transdermal absorption of theophylline and cianidanol

Fang

Tsai²,

Hung

et al. 2004

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

To improve the skin permeation of theophylline and cianidanol ((+)-catechin), the essential oil of Magnolia fargesii was evaluated using in-vitro and in-vivo permeation techniques. Oxygenated monoterpenes and sesquiterpenes are the major components of M. fargesii essential oil. The in-vitro permeation of theophylline and cianidanol was significantly enhanced after treatment with M. fargesii essential oil. The essential oil increased the in-vivo skin deposition of cianidanol but not theophylline. On the other hand, in-vivo microdialysis showed a higher subcutaneous theophylline amount after essential oil treatment. In-vitro cell viability and prostaglandin E(2) release by skin keratinocytes indicated that there was low or negligible cytotoxicity by M. fargesii essential oil. The in-vivo skin tolerance study determined by transepidermal water loss and colorimetry confirmed that no irritation of the skin was detected when using M. fargesii essential oil.

show abstract

Percutaneous absorption and skin erythema: Quantification of capsaicin and its synthetic derivatives from gels incorporated with benzalkonium chloride by using non-invasive bioengineering methods

Cited by 21 publications

References 39 publications

The Effect of Laser Treatment on Skin to Enhance and Control Transdermal Delivery of 5‐Fluorouracil

The Effect of Laser Treatment on Skin to Enhance and Control Transdermal Delivery of 5‐Fluorouracil

Challenges and Opportunities in dermal/transdermal Delivery

Development and evaluation of the essential oil from Magnolia fargesii for enhancing the transdermal absorption of theophylline and cianidanol

Contact Info

Product

Resources

About