Percutaneous absorption of hexachlorophene

Metabolism of hexachlorophene in the rabbit. Excretion, tissue distribution, and characterization of the urinary glucuronide conjugate

“…In the present study, rabbits excreted between 21 and 25% of the administered radioactive dose in the urine within 4 days. By contrast less than 10% of the HCP or its metabolites was recovered in the urine of other species of animals studied (St. John, Jr., and Lisk, 1972; Black et al, 1974;Buhler et al, 1977). The molecular weights of any HCP conjugates are sufficiently high that they would probably be excreted in the bile rather than by the kidney (Williams, 1971).…”

“…Early investigations concerning the metabolism of HCP suggested that orally administered HCP was slowly and incompletely absorbed (Wit and Van Genderen, 1962). Subsequent studies showed, however, that an oral dose of HCP was rapidly and almost completely absorbed (Buhler et al, 1977), and that the bis- phenol was metabolized in a number of species with the formation of a glucuronide conjugate (St. John, Jr., and Lisk, 1972; Black et al, 1974; Buhler et al, 1977). This conjugate, however, has not previously been isolated and identified in urine or feces.…”