Perfil clinicoepidemiológico dos melanomas cutâneos em duas instituições de referência na cidade de Manaus, Brasil

Chiba, Fabiano Bandeira; Schettini, Antônio Pedro Mendes; Delfino, Ana Carolina Guimaraes; Chirano, Carlos Alberto; Damasceno, Silvana De Albuquerque Silva

doi:10.1590/s0365-05962011000600036

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…However, in the north of Brazil, a previous study reported that the predominant subtype is acral lentiginous melanoma and most patients are non-white. 20 Further, there is a predominance of studies on the south of the country, while studies on the north and northeast are scarce.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Melanoma in the South of Brazil: study of a city in the Vale do Itajaí from 1999 to 2013

Lima

Stein

Casemiro³

et al. 2015

An. Bras. Dermatol.

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BACKGROUNDCutaneous melanoma is a highly aggressive malignancy with increasing incidence worldwide. The southern Brazilian state of Santa Catarina has one of the highest incidence rates of melanoma in the country.OBJECTIVETo evaluate the epidemiological profile of melanoma patients in a southern city of Brazil.METHODSa cross-sectional retrospective study was conducted, aiming to detect the clinical and histopathological characteristics of cutaneous melanoma diagnosed in the city of Brusque - SC, between 1999 and 2013.RESULTSA total of 213 cases in 212 individuals were studied. More than 50% of the patients were females (p< 0.05). The trunk was the most commonly affected site (p< 0.05), followed by the upper limbs. Nodular and superficial spreading melanomas were the most commonly detected in histological analyses. They did not differ statistically in frequency, but were more prevalent than other histopathological subtypes (p< 0.05). There was no statistically significant difference between invasive and noninvasive melanomas (p= 0.2441). Among the invasive melanomas, those with Breslow thicknesses < 1 mm and between 1-2mm were more prevalent (p< 0.05).CONCLUSIONSIn this study we found a higher frequency of melanomas in female patients and patients aged over 51. The trunk was the most commonly affected site. Nodular and superficial spreading melanomas prevailed. Among invasive melanomas, those with Breslow thicknesses < 2 mm were the most frequent. This paper highlights the epidemiological profile of melanoma patients in the city and may help to identify and aid in the follow-up of those who are most likely to present the disease.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Melanoma in the South of Brazil: study of a city in the Vale do Itajaí from 1999 to 2013

Lima

Stein

Casemiro³

et al. 2015

An. Bras. Dermatol.

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“…In Brazil, detailed population-based data on the incidence of CM according to demographic and histological characteristics are scarce. 25 Deficiency of compulsory notification, lack of reliable central registration, and lack of priority by public health managers are pointed out as the main barriers to a better understanding of the problem and the implementation of control actions. 25 …”

Section: Introductionmentioning

confidence: 99%

Epidemiological and histopathological aspects of primary cutaneous melanoma in residents of Joinville, 2003-2014

Steglich¹,

Coelho²,

Cardoso

et al. 2018

An. Bras. Dermatol.

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BackgroundThe worldwide incidence of cutaneous melanoma (CM) has been continuously increasing over the last decades. Primary and secondary prevention, with attention to risk factors and early diagnosis, remain the cornerstone for reducing the burden of cutaneous melanoma. Detailed information with respect to clinical and pathological data on cutaneous melanoma is scarce in Brazil.ObjectiveThe purpose of our study was to analyze epidemiological and pathological characteristics of primary cutaneous melanoma in Joinville, southern Brazil.MethodsObservational, cross-sectional, retrospective study in which 893 reports of primary cutaneous melanoma from the local population were analyzed in the period 2003-2014. The study was approved by the local Ethics and Research Committee.ResultsWe observed a female predominance of cutaneous melanoma (56.3%). The age standardized incidence rate of primary cutaneous melanoma for the world population in the period 2003-06 was 11.8 per 100,000 population (CI 95%, 10.3-13.4), and 17.5 (CI 95%, 15.7-19.3) in 2011-14, revealing a significant increase of 48.3% (p < 0,05). Six and a half percent of patients had multiple cutaneous melanomas (mean 2.2 years and a maximum of 10.0 years between diagnoses). We observed significant differences between the location head/neck and cutaneous melanoma in situ, lower limb with Breslow depth S III and upper limb with Breslow depth S I. The comparison of the characteristics of cutaneous melanoma in the elderly and non-elderly (< 60 years old) showed significant differences with respect to all the variables studied.Study limitationsUsing secondary data source.ConclusionJoinville has high incidence coefficients for Brazilian standards, showing an increase in the incidence of cutaneous melanoma.

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Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database

Wainstein¹,

Neto²,

Enokihara³

et al. 2020

JCO Global Oncology

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PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis.

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Perfil clinicoepidemiológico dos melanomas cutâneos em duas instituições de referência na cidade de Manaus, Brasil

Cited by 4 publications

References 8 publications

Epidemiology of Melanoma in the South of Brazil: study of a city in the Vale do Itajaí from 1999 to 2013

Epidemiology of Melanoma in the South of Brazil: study of a city in the Vale do Itajaí from 1999 to 2013

Epidemiological and histopathological aspects of primary cutaneous melanoma in residents of Joinville, 2003-2014

Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database

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