Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China

Yu, Shu; Feng, Weiyue; Liang, Zi-Mian; Zeng, Xianmin; Bloom, Michael S.; Hu, Guocheng; Zhou, Yang; Ou, Yanqiu; Chu, Chu; Li, Qingqing; Yu, Yunjiang; Zeng, Xiao‐Wen; Dong, Guang‐Hui

doi:10.1016/j.envpol.2021.117078

Cited by 39 publications

(8 citation statements)

References 82 publications

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“…Consistent with our study, previous studies also reported high concentrations of PFAS alternatives. For example, the plasma concentration of 6:2 Cl-PFESA concentration was 1.4 ng/mL in our study, which is comparable to 1.75 ng/mL reported by Yu et al 21 in the general population and 1.54 ng/mL by Chen et al 22 in pregnant women in China. Moreover, 6:2 Cl-PFESA, 8:2 Cl-PFESA and HFPO-DA were detected in more than 95% of our population, suggesting that humans are also widely exposed to the PFAS alternatives.…”

Section: Discussionsupporting

confidence: 86%

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Nian

Zhou

Feng

et al. 2022

Sci Rep

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Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals. Legacy PFAS have been phased out of production in most developed countries and emerging PFAS (short-chain PFAS and polyfluorinated compounds) are used as legacy PFAS alternatives. The effect of legacy and emerging PFAS on cytokine homeostasis in human remains poorly understood. This study aimed to evaluate the associations between legacy and emerging PFAS and cytokine profiles, and identify the main contributors to the disturbance of cytokine homeostasis. We quantified 21 PFAS in 198 Chinese women of childbearing age from 2015 to 2016. 13 cytokines were measured using the Meso Scale Discovery U-PLEX and V-PLEX platforms. The associations between PFAS exposure and cytokine levels were assessed using multiple linear regression (single-exposure), and Bayesian kernel machine regression (BKMR) models (PFAS mixture exposure). In single PFAS models, legacy and alternative PFAS were positively associated with Th1 and Treg cytokines, and negatively associated with Th2 and Th17 cytokines. For instance, each ln-unit increase in 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) was associated with a decrease in IL-10 by − 0.228 (95% CI: − 0.336, − 0.120), − 0.153 (95% CI: − 0.277, − 0.030), and − 0.174 (95% CI: − 0.339, − 0.010), respectively. The BKMR model showed a significantly positive association of PFAS mixture with TGF-β and a negative association with IL-10. Overall, these results indicate that both legacy and emerging PFAS may affect the homeostasis of cytokines.

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Section: Discussionsupporting

confidence: 86%

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Nian

Zhou

Feng

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Consistent with our study, previous studies also reported high concentrations of PFAS alternatives. For example, the plasma concentration of 6:2 Cl-PFESA concentration was 1.4 ng/mL in our study, which is comparable to 1.75 ng/mL reported by Yu et al 19 in the general population and 1.54 ng/mL by Chen et al 20 in pregnant women in China. Moreover, 6:2 Cl-PFESA, 8:2 Cl-PFESA and HFPO-DA were detected in more than 95% of our population, suggesting that humans are also widely exposed to the PFAS alternatives.…”

Section: Discussionsupporting

confidence: 86%

Emerging And Legacy PFAS And Cytokine Homeostasis In Women of Childbearing Age

Nian

Zhou

Feng

et al. 2022

Preprint

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The effect of legacy and emerging per- and polyfluoroalkyl substances (PFAS) on cytokine homeostasis in human remains poorly understood. This study aimed to evaluate the associations between legacy and emerging PFAS and cytokine profiles, and identify the main contributors to the disturbance of cytokine homeostasis. We quantified 21 PFAS in 198 Chinese women of childbearing age from 2015 to 2016. 13 cytokines were measured using the Meso Scale Discovery U-PLEX and V-PLEX platforms. The associations between PFAS exposure and cytokine levels were assessed using multiple linear regression (single-exposure), and Bayesian kernel machine regression (BKMR) models (PFAS mixture exposure). In single PFAS models, legacy and alternative PFAS were positively associated with Th1 and Treg cytokines, and negatively associated with Th2 and Th17 cytokines. For instance, each ln-unit increase in 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) was associated with a decrease in IL-10 by -0.228 (95% CI: -0.336, -0.120), -0.153 (95% CI: -0.277, -0.030), and -0.174 (95% CI: -0.339, -0.010), respectively. The BKMR model showed a significantly positive association of PFAS mixture with TGF-β and a negative association with IL-10. Overall, these results indicate that both legacy and emerging PFAS may affect the homeostasis of cytokines.

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“…However, the relationship of human exposure and overweight/ obesity status is still controversial, given concerns about reverse causality and effective dose (Jain 2020). Due to different modeling approaches and inconsistent confounding variables, the results of some studies were not consistent with ours (Averina et Though there is no evidence that showed Cl-PFESAs might be potential obesogens in human beings, our previous epidemiologic studies found serum Cl-PFESAs concentrations were signi cantly positively associated with serum lipids (Cong et al 2021) and the risk of metabolic syndrome (MetS) (Yu et al 2021). In addition, Yao et al (Yao et al 2020) reported multivariate linear regression coe cients of 9.80% (95% CI: 6.09, 13.63) for cholesterol (mmol/L), 9.59% (95% CI: 5.29, 14.07) for low-density lipoprotein cholesterol (mmol/L), 12.34% (95% CI: 2.80, 2.88) for triglycerides (mmol/L), higher 6:2 Cl-PFESA per lnng/mL concentrations, respectively, which suggests potential elevated lipid parameters from exposure to 6:2 Cl-PFESA.…”

Section: Discussioncontrasting

confidence: 61%

Non-monotonic Association Between Chlorinated Polyfluorinated Ether Sulfonic Acids Exposure and the Risk of Overweight/Obesity Status in Adults

et al. 2022

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BackgroundChlorinated poly uorinated ether sulfonic acids (Cl-PFESA 6:2 and 8:2), used as per uorooctane sulfonate (PFOS) alternatives, affect lipid metabolism in vivo and in vitro studies. The association between Cl-PFESAs exposure and the prevalence of overweight /obesity in human is unknown. ObjectivesWe investigated associations of serum 6:2 Cl-PFESA and 8:2 Cl-PFESA with overweight/obesity status in adults. MethodsWe quanti ed four per uoroalkyl substances (PFAS), including 6:2 Cl-PFESA, 8:2 Cl-PFESA, PFOS, and per uorooctanoic acid (PFOA) in 1275 Chinese adults from the Isomers of C8 Health Project in China study. Participants were categorized into normal weight group [body mass index (BMI) < 25 kg/m 2 ] and overweight/obesity group (BMI ≥ 25 kg/m 2 ). ResultsAdjusted for potential confounders, BMI in the second quartile of each ln-ng/mL greater concentration of 6:2 Cl-PFESA and 8:2 Cl-PFESA were 0.45 [95% con dence interval (CI): 0.08, 0.82], and 0.39 (95% CI:0.03, 0.76) signi cantly higher than the lowest quartile, respectively. Cl-PFESAs displayed inverted U-shaped associations with the risk of overweight/obesity, and the in ection point of 6:2 Cl-PFESA and 8:2 Cl-PFESA were 1.80 ng/mL, 0.01 ng/mL, respectively. PFOS was associated with waist circumference (WC) but not BMI in each quartile. For PFOA, the associations with outcomes were linearly positive (P for trend < 0.05). ConclusionsThis study reports the rst observations on non-monotonic associations between serum 6:2 Cl-PFESA and 8:2 Cl-PFESA concentrations and the prevalence of overweight/obesity in adults. More epidemiological investigations are required to con rm the observed associations.

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Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China

Cited by 39 publications

References 82 publications

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Emerging And Legacy PFAS And Cytokine Homeostasis In Women of Childbearing Age

Non-monotonic Association Between Chlorinated Polyfluorinated Ether Sulfonic Acids Exposure and the Risk of Overweight/Obesity Status in Adults

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