Objective: To assess the immune expressions of cytoplasmic and nuclear protein63 (p63) proteins in metaplastic triple-negative breast cancer (TNBC) patients with basal-like and non-basal-like types based on age.Methods: Forty samples of breast cancer patients diagnosed with TNBC were examined immune histochemical based on the immune expressions of cytoplasmic and nuclear p63 with basal-like (CK 5/6, positive) and non-basal-like (CK 5/6 negative) types. The histoscore values were categorized into Score 1 (<20%, negative), Score 2 (>20% -50%, weak positive), Score 3 (>50% -80%, moderate positive), and Score 4 (>80 %, strong positive) also analyzed by one-way analysis variance, probability (p<0.05), and correlation (p<0.01).Results: Forty subjects with breast cancer showed 23 of basal-like (57.5%) and 17 of non-basal-like (42.5%) types. The cytoplasmic p63 had a low histoscores in the group of < 40-49 years old (55%), the moderate group of 40-55 years old (27.5%), and the high group of fewer than 50-60 years old (17.5%). The nuclear p63 was low in all age groups (p<0.05). It was the significant difference between basal-like and non-basal-like types (p<0.01) and strongest correlation (1.00). The immunoexpression of cytoplasmic p63 of basal-like cell type had an intensity of 88.2%, while nuclear p63 possessed 11.8% (p<0.05).
Conclusion:The frequency of cytoplasm p63 in all age groups of metaplastic breast cancer of basal-like type was more dominant than the nuclear p63. Otherwise, in the non-basal-like type, the cytoplasmic p63 protein was lower than the of nuclear p63 protein.