Performance, antioxidant status, nutrient retention and serum profile responses of laying Japanese quails to increasing addition levels of dietary guanidinoacetic acid

Abstract

(2020) Performance, antioxidant status, nutrient retention and serum profile responses of laying Japanese quails to increasing addition levels of dietary guanidinoacetic acid,

Effects of arginine and guanidinoacetic acid with or without phenylalanine on ascites susceptibility in cold-stressed broilers fed canola meal-based diet

“…The plasma creatinine level was elevated by the dietary inclusion of 1.8 g/kg GAA. Similar results were observed when broilers [76] and Japanese quails [47] were fed diets supplemented with GAA. Creatinine is the end-product of skeletal muscle creatine and phosphocreatine degradation and diffuses from the muscle into the bloodstream before being excreted by the kidneys [77].…”

“…Ahmadipour et al [46], and Raei et al [47], increased NO concentrations were reported following GAA supplementation. According to an orthogonal contrast analysis, feeding experimental diets containing ARG and GAA with or without PHE also decreased RV to TV ratio, relative heart weight, and ascites mortality, possibly due to the higher plasma NO levels of birds fed these diets.…”

“…GAA has been observed to have an antioxidant effect, either directly or indirectly [60]. Ahmadipour et al [46] and Raei et al [47] indicated that the optimal level of the GAA exerts antioxidant activity, whereas high levels may serve as a prooxidant. Additionally, Amiri et al [81] concluded that adding 0.6 g/kg GAA significantly improved antioxidant status in broilers fed low-protein diets under heat stress.…”

“…There are a few studies on the effect of GAA supplementation on nutrient digestibility in broiler chickens. For instance, Raei et al [47] found that dietary supplementation of GAA at all tested levels (0.6, 1.2, and 1.8 g/kg) increased the digestibility of DM, CP, EE, and Ash in laying Japanese quails. However, in the present study, only EE digestibility improved following GAA supplementation.…”

Guanidinoacetic acid supplementation: A narrative review of its metabolism and effects in swine and poultry

“…Adding GAA to the diet does not seem to be an effective technique for boosting laying hen performance (Khakran et al, 2018). When laying quails were fed varied doses of dietary GAA supplementation (0, 0.6, 1.2, and 1.8 g/kg), the greatest laying rate was attained with 1.8 g/kg of GAA, while the optimum egg weight, egg mass, shell, and yolk weight was recorded with 1.2 g/kg of GAA (Raei et al, 2020). When laying hens were fed a reduced protein diet with supplemental GAA, egg production and feed intake decreased compared to the control diet (Dao et al, 2021).…”