THE SCIENCE OF fluid replacement in athletic training, particularly with regard to American football players, has advanced during the past 3 decades. This advance has resulted in substantial decreases in heatstroke-related deaths during summer training sessions. Recent trends in football heatstroke fatalities toward significant increases may, in part, be attributable to or aggravated by the use of dietary supplements. Credible scientific evidence has been found that amphetamine derivatives and the ergonomic aid creatine may contribute to subclinical dehydration and heatstroke in selected individuals. Caution is urged in the education and evaluation of football players who train during the hot summer months.
KEY WORDS: Amphetamines, Athletic fatalities, Creatine, Ephedrine, HeatstrokeNeurosurgery 51: 283-288, 2002 DOI: 10.1227 www.neurosurgery-online.com F atalities in organized sports have followed numerous trends through the years in which records have been maintained accurately. Despite rule changes, equipment improvements, and better education aimed at reducing the number of deaths or catastrophic injuries, a constant risk of such events nonetheless exists in modern athletics. Several recent highly publicized fatalities in organized sports have prompted great concern regarding a perceived increased incidence of death due to heatstroke and led us to this review and analysis of the available data concerning this phenomenon.Data obtained from the National Center for Catastrophic Sports Injury Research indicate that, during the past 3 decades, three distinct periods of heatstroke fatality trends in American football are evident (Fig. 1). The initial period (1965)(1966)(1967)(1968)(1969)(1970)(1971)(1972)(1973)(1974), which occurred before awareness of the dangers of dehydration in sports became prevalent, included 44 deaths, or 4.4/yr (22,29). After the publication of scientific evidence and reports of the advantages of proper hydration before and during practices and games, the next 10-year period (1975)(1976)(1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984) witnessed a total of 17 fatalities, or 1.7/yr (14,22,27). From 1985 to 1994, further developments led to greater understanding of the role of free access to water for hydration and rehydration as well as the promotion of policies and publicity that advocated active fluid replenishment, on a regular basis, with both free water and electrolytes. During this period, only six deaths secondary to dehydration and heatstroke were recorded, for a rate of only 0.6/yr (2,7,10,33).The events of the most recent period (1995)(1996)(1997)(1998)(1999)(2000)(2001), however, indicate a reversal of this downward trend, despite widespread dissemination of information to and education of athletic trainers, coaches, and players. The years 1995, 1998, and 2000 witnessed four deaths each, and three fatalities were reported in 2001; all occurred during the summer preseason American football conditioning and practice sessions. This recent increased incidence, highlighted by lay pre...