Performance of a restrictive flow device and an electronic syringe driver for continuous subcutaneous infusion

Capes, D F; Martin, Karen; Underwood, Rod

doi:10.1016/s0885-3924(97)00181-4

Cited by 10 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Springfusor has a per-use consumable cost of $4.40–$9.40 for flow-controlled tubing and is only compatible with 10 mL and 30 mL Braun Syringes [17, 18]. During this study, B-D syringes and tubing were used to connect AutoSyp to the patient.…”

Section: Discussionmentioning

confidence: 99%

“…Administering MgSO 4 intravenously to reduce patient discomfort in low-resource settings is supported in the study of the Springfusor IV pump, a completely mechanical pump which straps to the patient’s arm to deliver MgSO 4 therapy; over 95% percent of subjects with Springfusor reported pain levels associated with MgSO 4 administration as acceptable or very acceptable [ 10 ]. However, Springfusor has a per-use consumable cost of $4.40–$9.40 for flow-controlled tubing and is only compatible with 10 mL and 30 mL Braun Syringes [ 17 , 18 ]. During this study, B-D syringes and tubing were used to connect AutoSyp to the patient.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a low-cost, low-power syringe pump to deliver magnesium sulfate intravenously to pre-eclamptic women in a Malawian referral hospital

Skerrett

Kommwa

Maynard

et al. 2017

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundMagnesium sulfate is an affordable and effective treatment for pre-eclampsia and eclampsia. In settings where infusion pumps are not available to regulate the flow rate of intravenous delivery, healthcare providers must administer magnesium sulfate (MgSO4) via time-consuming and painful, large-volume intramuscular injections. As an alternative to costly commercially available syringe pumps, we developed AutoSyp, an accurate, low-cost, and low-powered syringe pump designed to meet the needs and constraints these low-resource settings. This paper describes results of a pilot study to evaluate the feasibility of using AutoSyp to administer MgSO4 intravenously to women suffering from pre-eclampsia at a referral hospital in Blantyre, Malawi.MethodsAutoSyp was programmed to deliver MgSO4 following the Zuspan regimen to pregnant and post-partum women suffering from pre-eclampsia at Queen Elizabeth Central Hospital in Blatnyre, Malawi. Given the selection of either loading or maintenance dose on AutoSyp’s user interface, the flow rate was automatically programmed to dispense 60 mL/h or 5 mL/h of 20% MgSO4 solution, respectively. During each treatment, the dispensed volume was automatically calculated by the device based on the plunger position and stored on a computer for accuracy analysis of the mean flow rate and total volume delivered. The clinical results for both the loading and maintenance dose administrations were compared to the device’s accuracy during tests performed in the laboratory setting.ResultsTwenty-two women were enrolled in this study. In both the clinical and laboratory settings, the mean flow rate errors for the loading and maintenance dose infusions were under 2%. During 466 h of testing, the device sounded 129 occlusion alarms across 14 subjects. Of these, 71 alarms were false positives.ConclusionResults of this study support the use of AutoSyp as a less painful and accurate means of MgSO4 administration in clinical environments that lack infusion systems.There were a large number of false alarms in the current system which will be addressed in future designs. AutoSyp maintains the comfort of intravenous MgSO4 administration, but unlike commercially available syringe pumps, it is capable of operating with a variety of syringe brands and sizes and requires no additional consumables. AutoSyp’s appropriate design will benefit its implementation and sustained use in low-resource settings.Trial RegistrationTrial registered prospectively on November 18, 2014 with ClinicalTrials.gov (NCT02296931)

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of a low-cost, low-power syringe pump to deliver magnesium sulfate intravenously to pre-eclamptic women in a Malawian referral hospital

Skerrett

Kommwa

Maynard

et al. 2017

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Alternatives to electronic devices include continuous manual monitoring of an intravenous (IV) administration and nonelectric flow-restricting infusion pumps [9]. Manual monitoring is labor intensive and not always feasible.…”

Section: Introductionmentioning

confidence: 99%

Design of a Novel, Adjustable Flow Rate, Reusable, Electricity-Free, Low-Cost Syringe Infusion Pump

Guelig

Bauer

Wollen

et al. 2017

Journal of Medical Devices

View full text Add to dashboard Cite

We present a proof-of-concept design and preliminary data to demonstrate a novel syringe infusion pump that is low cost, nonelectric, reusable, and adjustable. This device addresses the need for infusion therapy in low- and middle-income countries (LMIC), where intermittent electrical power precludes the use of conventional electronic infusion pumps and limited financial resources make high costs of disposable infusion pumps impractical. Our design uses a pneumatically pressurized, hydraulic (air over oil) drive piston coupled to a closed-circuit flow restriction to drive a syringe plunger at a constant velocity, thus providing a constant volumetric flow rate to the patient. The device requires no proprietary or precision consumables, significantly reducing treatment costs compared with other methods. The highly adjustable device provides constant flow rates across the range of 0.5–8 mL/h when used with a 30-mL syringe. The user interface is simple and intuitive; the hardware is robust and portable. This novel technology platform has broad applications in addressing priority health needs in LMIC.

show abstract

“…There are quite a lot of different actuation technologies for infusion pumps. Actuators can be as simple as a spring 4 [6] or an elastic membrane 5 . Pumps with gas generators are also state-of-the-art 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Actuators can be as simple as a spring 4 [6] or an elastic membrane 5 . Pumps with gas generators are also state-of-the-art 6 . Electromechanical syringe drivers are used when there are demanding requirements on the flow rate and/or occlusion detection is necessary.…”

Section: Introductionmentioning

confidence: 99%

A flat and cost effective actuator based on superabsorbent polymer driving a skin attachable drug delivery system

Vosseler

Clemenz

Zengerle

2012

Smart Mater. Struct.

View full text Add to dashboard Cite

We present a flat and cost effective volume displacement actuator based on superabsorbent polymer. It offers slow kinetics and is able to work against reasonable back-pressures, e.g. 0.50 ml in 235 min at 140 kPa. It is predestined for low-cost skin attachable drug delivery devices. The actuator consists of a plastic ring filled with superabsorbent polymer granulate. It is sealed with a thermoplastic elastomeric membrane on one side and a stiff filter membrane on the other side. After adding a defined amount (e.g. 2 or 10 ml) of swelling agent the actuator shows a fast initial volume displacement within a few minutes followed by a slow continuous increase of this volume within hours. Minimized initial volume displacement and maximized displaced volume after 4 h cannot be combined in one actuator. A minimized initial displacement can be as low as 0.10 ml ± 0.03 ml. A maximized displaced volume after 4 h can be 1.71 ml ± 0.18 ml, not considering the initial effect. The back-pressure dependency of one selected actuator design was studied. At a back-pressure of 100 kPa the displaced volume is reduced by 33%. We investigated various actuator designs with varying surface area, hardness of the elastomeric membrane and superabsorbent polymer. Finally, we demonstrate a skin attachable drug delivery system based on the employment of the superabsorbent polymer actuator.

show abstract

Performance of a restrictive flow device and an electronic syringe driver for continuous subcutaneous infusion

Cited by 10 publications

References 14 publications

Evaluation of a low-cost, low-power syringe pump to deliver magnesium sulfate intravenously to pre-eclamptic women in a Malawian referral hospital

Evaluation of a low-cost, low-power syringe pump to deliver magnesium sulfate intravenously to pre-eclamptic women in a Malawian referral hospital

Design of a Novel, Adjustable Flow Rate, Reusable, Electricity-Free, Low-Cost Syringe Infusion Pump

A flat and cost effective actuator based on superabsorbent polymer driving a skin attachable drug delivery system

Contact Info

Product

Resources

About