Performance of T2 Maps in the Detection of Prostate Cancer

Chatterjee, Aritrick; Devaraj, Ajit; Mathew, Melvy Sarah; Szasz, Teodora; Antic, Tatjana; Karczmar, Gregory S.; Oto, Aytekin

doi:10.1016/j.acra.2018.04.005

Cited by 30 publications

(38 citation statements)

References 21 publications

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“…The overall sensitivity and PPV in detecting prostate cancers using T2W images in this study are similar to values published literature on T2W imaging of the prostate (2,21,(30)(31)(32)(33). While, our study suggests the use of longer TE for T2W imaging of the prostate, the readers should be careful in ascertaining the optimal TE.…”

Section: Discussionsupporting

confidence: 87%

“…Exclusion criteria included any prior radiation or hormonal replacement therapy. Exclusion of cases in this study, included 11 cases where no multi-echo T2W images were acquired and 35 cases where multi-echo T2W imaging was performed using research k-t-T2 research sequence (21,24) that used different imaging parameters instead of TSE. The final set included 38 patients.…”

Section: Study Patientsmentioning

confidence: 99%

“…While the choice of TE in diffusion weighted imaging has been studied and shown to alter measurements and diagnostic performance (15), there is little available data regarding how different TEs affects the performance of T2-weighted images for the detection of prostate cancer. For instance, there are no standard clinical imaging parameters for echo time (TE) for T2W imaging, and the reported TEs used at several major institutions vary from 90 to 120 ms (16)(17)(18)(19)(20)(21)(22)(23). This variability makes meta-data analysis and comparing images and radiologist performance across institutions difficult, and it is unclear whether some TEs are superior to others.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images

et al. 2020

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Section: Discussionsupporting

confidence: 87%

Section: Study Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images

et al. 2020

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“…In our study, the average T2 values in the peripheral and transition zones were 173.4 and 121.4 ms, respectively. On the other hand, the T2 values in the peripheral zone in previous studies varies from 149 ms to 211 ms by conventional T2 mapping techniques on 3T MRI [ 5 16 17 ]. In previous MRF studies, the T2 values were 169 and 65 ms in the peripheral and transition zones, respectively [ 10 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, T1 or T2 mapping is necessary for the quantification of T1 and T2 values to obtain the objective parameters. Previous studies on T1 or T2 maps have shown promising results in differentiating prostate cancer from normal tissue and in determining the aggressiveness of prostate cancers [ 3 4 5 6 7 8 9 ]. However, the length of time needed to acquire T1 and T2 maps hinders their clinical use, and these maps cannot replace the conventional T1- and T2WI.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Novel Three-Dimensional Magnetic Resonance Fingerprinting of the Prostate Gland: Phantom and Clinical Studies

Han¹,

Choi

Lee

et al. 2021

Korean J Radiol

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Objective To evaluate the feasibility of a new three-dimensional (3D) MR fingerprinting (MRF) technique for the prostate gland by conducting phantom and clinical studies. Materials and Methods The new 3D MRF technique used in this study enables quick data acquisition and has a high resolution. For the phantom study, the MRF T1 and T2 values in an in-house phantom were compared with those of gold-standard mapping methods using linear regression analysis. For the clinical study, we evaluated 90 patients who underwent prostate imaging with MRF for suspected prostate cancer between September 2019 and February 2020. The mean T1 and T2 values were compared in the peripheral zone, transition zone, and focal lesions using paired t tests. The differences in the T1 and T2 values according to cancer aggressiveness were evaluated using one-way analysis of variance. Results In the phantom study, the MRF T1 and T2 values showed a perfect correlation with the gold-standard T1 and T2 values (R > 0.99). In the clinical study, the T1 and T2 values in the peripheral zone were significantly higher than those in the transitional zone ( p < 0.001, both). The T1 and T2 values in prostate cancer were significantly lower than those in the peripheral and transitional zones. The higher the grade of cancer, the lower the T2 values. Conclusion The T1 and T2 values obtained from the 3D MRF showed a perfect correlation with the gold standard values in the phantom study. Differences in the T1 and T2 values among the different zones of the prostate gland were identified using 3D MRF in patients.

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Utility of Quantitative T2‐Mapping Compared to Conventional and Advanced Diffusion Weighted Imaging Techniques for Multiparametric Prostate MRI in Men with Hip Prosthesis

Sathiadoss

Schieda

Haroon

et al. 2021

Magnetic Resonance Imaging

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P rostate MRI is an integral component in the care of men with suspected or confirmed prostate cancer (PCa). A fundamental imaging component for detection of PCa with MRI is high-quality diffusion weighted imaging (DWI) 1,2 ; DWI is the determining sequence for the assessment of the peripheral zone (PZ) and also plays a critical role in evaluating the transition zone (TZ). 3 DWI is most commonly performed using echo planar imaging (EPI), 4 however, a challenge with EPI is its sensitivity to magnetic susceptibility artifacts. [5][6][7] Sensitivity to susceptibility artifact on DWI is particularly problematic in men with hip prostheses or other metallic hardware. 8 When DWI is suboptimal or non-diagnostic, a reader may use dynamic contrast enhanced (DCE)-MRI as a surrogate for DWI combined with T2-weighted (T2W) imaging, 9 however, at the cost of lower diagnostic performance particularly in the TZ. [10][11][12] Alternative EPI-DWI techniques have been studied, including reduced or zoomed field-of-view (FOV) EPI-DWI and segmented readout EPI-DWI, which may improve image quality compared to conventional EPI-DWI; however, these remain limited in men with hip replacements. [13][14][15] The use of a PROPELLER based fast spin echo (FSE)-DWI sequence has also been studied in men with hip replacement with some preliminary success 8 ; however, this has lacked validation and commercial availability for the prostate application.Quantitative T2-mapping is a technique which has been previously studied and validated for PCa detection and characterization. 16,17 T2 maps offer similar information to apparent diffusion coefficient (ADC) maps derived from DWI. 17 Both ADC and T2 relaxation times have been shown to be good indicators of cell density, 18 with the potential to predict tumor aggressiveness. Advantages of quantitative T2-maps, compared to DWI, include: more reproducible quantitative values [19][20][21] and less vulnerability to magnetic susceptibility artifacts, since these sequences are spin-echo based. 22 The purpose of this study was therefore to evaluate T2-mapping in men with hip prosthesis undergoing prostate MRI and to compare image quality and impact on the interpretation to conventional and variant DWI techniques in the same prospective patient cohort.

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Performance of T2 Maps in the Detection of Prostate Cancer

Abstract: Our study shows that review of T2 maps by radiologists has similar sensitivity but higher PPV compared to T2W images. Additional quantitative information obtained from T2 maps is helpful in differentiating cancer from normal prostate tissue and determining its aggressiveness.

Cited by 30 publications

References 21 publications

Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images

Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images

Feasibility of Novel Three-Dimensional Magnetic Resonance Fingerprinting of the Prostate Gland: Phantom and Clinical Studies

Utility of Quantitative T2‐Mapping Compared to Conventional and Advanced Diffusion Weighted Imaging Techniques for Multiparametric Prostate MRI in Men with Hip Prosthesis

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