Performance of Ticks Fed on Rabbits Inoculated with Extracts Derived from Homogenized Ticks Amblyomma maculatum Koch (Acarina: Ixodidae)

McGowan, Michael J.; Homer, John T.; Odell, George V.; McNew, R. W.; Barker, R. W.

doi:10.2307/3280586

Cited by 22 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the frequent ticks in the world is Rhipicephalus and the species of Rh.annulatus is abundant in north of Iran (16)(17). This tick leads to economic losses due to sucking blood and transmission of pathogens such as Anaplasma and Babesia in cattle industry (18)(19). Although the chemical control is one of the oldest and the most powerful methods of tick control (20), such method is unendurable, timeconsuming, and costly; thus, attempts are toward designing vaccines based on immunogenic peptides with prediction methods based on amino acid sequence and physico-chemical characteristics (accessibility, flexibility, hydrophobicity, antigenic propensity, exposed surface, turns) (7).…”

Section: Discussionmentioning

confidence: 99%

Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva

Asadollahi

Nabian

Taheri

et al. 2018

JBRMS

View full text Add to dashboard Cite

Introduction: Regarding emerging tick resistance against acaricides, researches have been shifted toward alternative approaches such as immunologic methods. Vaccine preparation is an alternative way in which choosing appropriate protein with high immune induction potency is a prerequisite. In addition according to studies, using more than one protein could better enhance the immune induction and antibody production. Choosing immunogenic epitopes from selected proteins and adjoining them with a suitable linker is one of the novel approaches in vaccine design. Materials and methods: Based on the fact that both cathepsin and tropomyosin proteins of Rhipicephalus tick were previously recognized as potent immunogenic antigens, we predicted the immunogenic epitopes of these proteins by immunoinformatic methods. Among studied epitopes, those that were met by multiple bioinformatics tools were used. Results: Finally, the polytopic construction was designed by assembling the selected epitopes and connecting them with linkers. Conclusion: Using immunoinformatic tools, we predicted the characteristics of two genes of Rhipicephalus annulatus tick larva as fused potent vaccine candidates namely, cathepsin and tropomyosin.

show abstract

Section: Discussionmentioning

confidence: 99%

Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva

Asadollahi

Nabian

Taheri

et al. 2018

JBRMS

View full text Add to dashboard Cite

show abstract

“…Researchers have used extracts of eggs, of larvae, of nymphs, of partially engorged females of adult ticks, of salivary glands, of saliva and the cement as antigenic sources. These antigens produced an immune response, but a challenge with a homologous tick rarely showed a positive correlation with the response obtained (Gregson, 1941(Gregson, , 1970Riek, 1958;1959;Tornado & Gutierrez, 1967;McGowan et al, 1980;Labarthe, 1981;Berne, 1982, Wilkinson & Allen, 1983Brown et al, 1984;Johnston et al, 1986;Gordon & Allen, 1987).…”

Section: Literature Reviewmentioning

confidence: 99%

Biological control of tick populations: review and reflections

Labarthe

1994

Cad. Saúde Pública

View full text Add to dashboard Cite

show abstract

“…Interestingly, the rabbit model was the first animal model used in several immunological studies and was crucial, for example, in the development of Louis Pasteur's rabies vaccine in 1881 [50]. In 1976, the World Health Organization (WHO) [51] highlighted rabbits as among the most important laboratory animals for the study of different diseases [51][52][53][54]. The most common breeds of laboratory rabbits are derived from the European rabbit (Oryctolagus cuniculus) [55].…”

Section: Introductionmentioning

confidence: 99%

Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario

Rodríguez-Durán,

Ullah,

Parizi

et al. 2023

Pathogens

View full text Add to dashboard Cite

Studies evaluating candidate tick-derived proteins as anti-tick vaccines in natural hosts have been limited due to high costs. To overcome this problem, animal models are used in immunization tests. The aim of this article was to review the use of rabbits as an experimental model for the evaluation of tick-derived proteins as vaccines. A total of 57 tick proteins were tested for their immunogenic potential using rabbits as models for vaccination. The most commonly used rabbit breeds were New Zealand (73.8%), Japanese white (19%), Californians (4.8%) and Flemish lop-eared (2.4%) rabbits. Anti-tick vaccines efficacy resulted in up to 99.9%. Haemaphysalis longicornis (17.9%) and Ornithodoros moubata (12.8%) were the most common tick models in vaccination trials. Experiments with rabbits have revealed that some proteins (CoAQP, OeAQP, OeAQP1, Bm86, GST-Hl, 64TRP, serpins and voraxin) can induce immune responses against various tick species. In addition, in some cases it was possible to determine that the vaccine efficacy in rabbits was similar to that of experiments performed on natural hosts (e.g., Bm86, IrFER2, RmFER2, serpins and serine protease inhibitor). In conclusion, results showed that prior to performing anti-tick vaccination trials using natural hosts, rabbits can be used as suitable experimental models for these studies.

show abstract

Performance of Ticks Fed on Rabbits Inoculated with Extracts Derived from Homogenized Ticks Amblyomma maculatum Koch (Acarina: Ixodidae)

Cited by 22 publications

References 18 publications

Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva

Designing of potential vaccine candidates of fused cathepsin L and tropomyosin genes of Rhipicephalus (Boophilus) annulatus tick larva

Biological control of tick populations: review and reflections

Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario

Contact Info

Product

Resources

About