Pericardial Mesothelioma in a Neonatal Calf

Takasu, Masaki; Shirota, Kinji; Uchida, Naohiro; Iguchi, Tomonori; Nishii, Naohito; Ohba, Yasunori; Maeda, Sadatoshi; Miyazawa, Keiji; Murase, Tetsuma; Kitagawa, Hitoshi

doi:10.1292/jvms.68.519

Cited by 20 publications

(10 citation statements)

References 8 publications

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“…36 This antibody panel has not been applied previously to bovine lesions; bovine pericardial and peritoneal 1 2 3 3 2 3 2 0 0 2 2 3 2 2 2 1 0 0 3 2 2 3 2 2 1 0 0 4 2 3 3 2 2 1 0 0 5 2 3 2 2 2 3 0 0 6 2 2 3 3 2 3 0 0 7 2 3 3 2 3 1 0 0 8 2 3 3 2 3 mesotheliomas have been characterized immunohistochemically only by co-expression of cytokeratins and vimentin. 10,35 In the dog, mesotheliomas have been shown to be immunoreactive for pan-cytokeratin, cytokeratin 5/6, vimentin, calretinin, and WT1. 3,9,23,32,33 Ultrastructurally, elongated, thin microvilli at the cell surface, together with well-formed desmosomes and tonofibrils, support a mesothelial origin as in human ATs.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Adenomatoid Tumor in Eight Cattle: Evidence for Mesothelial Origin of Bovine Myocardial Epithelial Inclusions

et al. 2009

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The adenomatoid tumor is an uncommon benign lesion, thus far described only in humans. Adenomatoid tumors typically arise in the genital tract, exceptionally in the heart, and usually represent an incidental finding. Microscopically, they are constituted by epithelioid cells that form tubular structures and anastomosing channels within a fibrous stroma. Mesothelial origin of these lesions is suggested by their immunohistochemical characteristics. In cattle, previously reported myocardial epithelial inclusions are morphologically similar in that the cells are immunoreactive for both cytokeratins and vimentin, and bear surface microvilli. Myocardial lesions found incidentally at slaughter in 8 cattle histologically resembled the so-called bovine myocardial epithelial inclusions and had morphologic and immunohistochemical features consistent with human adenomatoid tumor. All lesions were in the left ventricular myocardium, adjacent to the epicardium, and composed of epithelioid cells that formed cords and tubules, and were immunoreactive for pan-cytokeratins, cytokeratin 5/6, vimentin, calretinin, Wilms' tumor 1 suppressor gene, and CD30 antigen. By electron microscopy, numerous long slender microvilli were associated with desmosomes and tonofibrils. The immunohistochemical and ultrastructural features were considered consistent with mesothelial origin. These lesions, corresponding to the previously described myocardial epithelial inclusions in cattle, might be considered embryologic rests and could represent the bovine counterpart of the human adenomatoid tumor.

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Section: Discussionmentioning

confidence: 99%

Myocardial Adenomatoid Tumor in Eight Cattle: Evidence for Mesothelial Origin of Bovine Myocardial Epithelial Inclusions

et al. 2009

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“…Histology of the necropsy specimen in the present case could contribute to a definitive diagnosis of peritoneal mesothelioma together with immunohistochemistory, in which the neoplastic cells were positive for both epithelial and mesenchymal marker intermediate filaments (cytokeratin and vimentin) [11, 30] In bovines, potential difficulties associated with histologic examinations have been described; variations of mitotic figures were observed rarely [2, 5, 10, 11] or commonly [4], and hyperplastic reactions of mesothelial cells induced by the effects of various abdominal diseases frequently resemble histologic characteristics of peritoneal mesothelioma [27]. However, these difficulties can be minimized by collecting specimens in which the structures are definitively maintained and similar to those formed within the nodules.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf

et al. 2019

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BackgroundPeritoneal mesothelioma is a rare abdominal disease; that occasionally occurs congenitally in younger calves. Cytologic examination of peritoneal effusion (PE) was utilized to diagnose this disease, and was not diagnostic. Diagnostic accuracy has been elevated by recent use of ultrasonography (US), despite most diagnoses have been obtained post-mortem in slaughter houses or during clinical necropsy. In humans, ante-mortem diagnosis is highly associated with clinical use of computed tomography (CT) and laparoscopy together with imaging-assisted biopsy. The present report evaluates the diagnostic applicability of CT and laparoscopy as well as US via the practical application of these imaging modalities in an affected calf, and compares the cytologic and histologic findings among in PE, and specimens obtained from fine-needle aspiration and core-needle biopsy. In addition, the present results were reviewed in comparison with those of previous bovine and human reports.Case presentationA 58-day-old male Japanese black calf presented first with scrotal swelling, followed by progressive abdominal distention. Abnormalities of the case included: 1) accumulation of anechoic PE inside the swollen scrotum and abdomen; 2) formation of multiple echogenic nodules within the peritoneal membrane based on US images; 3) presence of hyper-dense spots (suspected calcification) along the margins of the nodules; 4) anatomic connections between intra-abdominal nodular lesions and the swollen tunica vaginalis via the inguinal region based on CT images; 5) serosanguineous-colored and less-turbid characteristics of PE; and 6) formation of multiple nodules over all of the serosa of the rumen as well as the peritoneal wall based on laparoscopic views. Fine-needle aspiration and core-needle biopsy were successfully performed under US and laparoscopic observations, respectively. Histology findings of the core-needle biopsy specimen appeared more indicative (characterization of tubular structures comprised of cubical or columnar abnormal mesothelial cell linings) diagnostically of peritoneal mesothelioma than did findings of the fine-needle aspiration specimen.ConclusionsTo the best of our knowledge, this report is the first description of clinical applications of CT and laparoscopy to diagnose peritoneal mesothelioma in a calf. Laparoscopy enhanced the diagnostic accuracy due to clear gross visualization of the intra-abdominal abnormalities and applicability to imaging-guided core-needle biopsy.

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“…Some reports in animals describe positive reaction for cytokeratin and vimentin in mesothelial cells (9,26,28). Intrapericardial development of mesothelioma was described in neonatal calf with the neoplastic cells presenting positivity for both cytokeratin and vimentin (26).…”

Section: Discussionmentioning

confidence: 99%

Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report

Toledo¹,

Gonçalves²,

Toscano³

et al. 2018

BJVP

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Toledo, et al.; Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report. Braz J Vet Pathol, 2018, 11(2), 68 -75 DOI: 10.24070/bjvp.1983 Abstract Mesothelioma is a rare tumor of mesothelium and usually spread by implantation in the same cavity it arises. Regarding bovine mesotheliomas, the abdominal cavity is the most affected site. This article describes a case of diffuse papillary mesothelioma within both thoracic and abdominal cavity with nodal metastasis in an adult cow -based on cytology, histopathology, and immunohistochemical analysis. A 7-years-old cow, Nelore breed (Brazilian beef cattle), with clinical signs of tachypnea, abdominal distention, and positive jugular venous pulse was slaughtered and necropsied due to persistent weight loss. The main gross findings were several verrucous and yellowish nodules spread on pericardium, pleura, and peritoneum. Mediastinal lymph nodes were enlarged and hemorrhagic with multiples yellowish spots on cut surface. The diagnoses of diffuse mesothelioma with nodal metastasis was established and ratified by the microscopic analysis. Immunohistochemical results had strong positivity for cytokeratin and the Ki-67 showed proliferative index of 28%. Vimentin was positive only in the cells of fibrous tissue. In this case, the initial site of the mesothelioma was not recognized. Although it is a post-mortem study, cytology may be very helpful in vivo investigation. Equally important, is the IHC to better comprehend this tumor and its behavior.

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Pericardial Mesothelioma in a Neonatal Calf

Cited by 20 publications

References 8 publications

Myocardial Adenomatoid Tumor in Eight Cattle: Evidence for Mesothelial Origin of Bovine Myocardial Epithelial Inclusions

Myocardial Adenomatoid Tumor in Eight Cattle: Evidence for Mesothelial Origin of Bovine Myocardial Epithelial Inclusions

Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf

Diffuse thoracic and peritoneal papillary mesothelioma in an adult cow: case report

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