Pericytes in the tumor microenvironment

Jiang, Zhongyi; Zhou, Jing; Li, Luohong; Liao, Shan; He, Junyu; Zhou, S. Kevin; Zhou, Yanhong

doi:10.1016/j.canlet.2023.216074

Cited by 49 publications

(18 citation statements)

References 107 publications

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“…Lastly, adipocytes are closely related to cancer cells. They release free fatty acids, hormones, cytokines, adikines, and growth factors that affect cancer cells and host cells in TME [ 29 , 30 ].…”

Section: Background Knowledge Of Cafsmentioning

confidence: 99%

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Zhang,

Yue,

Chen

et al. 2023

Mol Cancer

102

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Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment. The versatility and sophisticated mechanisms of CAFs in facilitating cancer progression have been elucidated extensively, including promoting cancer angiogenesis and metastasis, inducing drug resistance, reshaping the extracellular matrix, and developing an immunosuppressive microenvironment. Owing to their robust tumor-promoting function, CAFs are considered a promising target for oncotherapy. However, CAFs are a highly heterogeneous group of cells. Some subpopulations exert an inhibitory role in tumor growth, which implies that CAF-targeting approaches must be more precise and individualized. This review comprehensively summarize the origin, phenotypical, and functional heterogeneity of CAFs. More importantly, we underscore advances in strategies and clinical trials to target CAF in various cancers, and we also summarize progressions of CAF in cancer immunotherapy.

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Section: Background Knowledge Of Cafsmentioning

confidence: 99%

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Zhang,

Yue,

Chen

et al. 2023

Mol Cancer

102

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“…In addition, the Ang-2/Tie signalling and VEGF signalling pathways synergistically promote tumour neo-angiogenesis, blockade of Ang-2 and VEGF delays tumour growth and enhances survival benefits through reprogramming of tumour-associated macrophages toward an antitumour phenotype as well as by pruning immature tumour vessels ( 25 ). Pericytes release Ang-1, which binds to endothelial cell TIE2 receptors, thereby efficiently inhibiting endothelial cell proliferation and promoting angiogenesis stability through downstream signalling pathways, such as Calpain, protein kinase B, and forkhead box O3A ( 26 ).…”

Section: Different Mechanisms Of Angiogenesismentioning

confidence: 99%

Mechanisms of angiogenesis in tumour

Zhang,

Yao,

Gao

et al. 2024

Front. Oncol.

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Angiogenesis is essential for tumour growth and metastasis. Antiangiogenic factor-targeting drugs have been approved as first line agents in a variety of oncology treatments. Clinical drugs frequently target the VEGF signalling pathway during sprouting angiogenesis. Accumulating evidence suggests that tumours can evade antiangiogenic therapy through other angiogenesis mechanisms in addition to the vascular sprouting mechanism involving endothelial cells. These mechanisms include (1) sprouting angiogenesis, (2) vasculogenic mimicry, (3) vessel intussusception, (4) vascular co-option, (5) cancer stem cell-derived angiogenesis, and (6) bone marrow-derived angiogenesis. Other non-sprouting angiogenic mechanisms are not entirely dependent on the VEGF signalling pathway. In clinical practice, the conversion of vascular mechanisms is closely related to the enhancement of tumour drug resistance, which often leads to clinical treatment failure. This article summarizes recent studies on six processes of tumour angiogenesis and provides suggestions for developing more effective techniques to improve the efficacy of antiangiogenic treatment.

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“…Functionally, the recruitment of pericytes is important in mediating blood flow as they contribute to regulating both vasoconstriction and vasodilation (49). Pericytes have recently become a topic of interest in the study of pathological tumor growth as vasculature within tumors has demonstrated dysregulation in pericyteendothelial cell interactions leading to abnormal blood vessel sprouting (42,50). Additionally, abnormal pericyte death contributes to diabetic retinopathy, as altered blood flow in the retina contributes to vascular leakage resulting in decreased vision acuity (51-56).…”

Section: Cellular Metabolic Pathways In Lymphangiogenesis 21 Glycolysismentioning

confidence: 99%

The role of lymphatic endothelial cell metabolism in lymphangiogenesis and disease

Simeroth,

2024

Front. Cardiovasc. Med.

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Lymphatic endothelial cells (LECs) line lymphatic vessels, which play an important role in the transport of lymph fluid throughout the human body. An organized lymphatic network develops via a process termed “lymphangiogenesis.” During development, LECs respond to growth factor signaling to initiate the formation of a primary lymphatic vascular network. These LECs display a unique metabolic profile, preferring to undergo glycolysis even in the presence of oxygen. In addition to their reliance on glycolysis, LECs utilize other metabolic pathways such as fatty acid β-oxidation, ketone body oxidation, mitochondrial respiration, and lipid droplet autophagy to support lymphangiogenesis. This review summarizes the current understanding of metabolic regulation of lymphangiogenesis. Moreover, it highlights how LEC metabolism is implicated in various pathological conditions.

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Pericytes in the tumor microenvironment

Cited by 49 publications

References 107 publications

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Mechanisms of angiogenesis in tumour

The role of lymphatic endothelial cell metabolism in lymphangiogenesis and disease

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