Perinatal Outcome in Maternal COVID-19 infection at a Tertiary care Institute- A cross Sectional Study

Asalkar, Mahesh; Thakkarwad, Smita; Bacchewad, R. P.; Sharma, Nitika

doi:10.1007/s13224-022-01673-4

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Regarding neonatal outcomes, regarding neonatal length, birthweight, head circumference and Apgar score, we observed no significant differences between cases and controls. These findings are consistent with the literature, particularly in reference to the alpha variant of SARS-CoV-2 [ 42 , 43 , 44 ]. There are differences in the response of the immune system (in the mother and fetus) and symptoms among SARS-CoV-2 variants [ 45 , 46 ].…”

Section: Discussionsupporting

confidence: 93%

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

et al. 2023

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COVID-19 is characterized by the immune system’s overreaction resulting in a ‘cytokine storm’, consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is further complicated in case of infection of patients with a peculiar immunological status, such as pregnancy. In this paper, we focused on Interferon-γ, which plays a pivotal immunomodulatory role in normal pregnancy and fetal development, as well as in defense against pathogens. In this study, we compared the levels of Interferon-γ and the Interferon autoantibodies of the peripheral and cord blood of pregnant women with confirmed mild COVID-19 and healthy pregnant women. The Interferon-γ was significantly lower both in the peripheral and cord blood of SARS-CoV-2-positive mothers, suggesting that infection can affect the fetal microenvironment even without severe maternal symptoms. In conclusion, further studies are needed to clarify whether lower levels of Interferon-γ due to SARS-CoV-2 infection affect the development or infection susceptibility of infants born to SARS-CoV-2-infected mothers.

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Section: Discussionsupporting

confidence: 93%

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

et al. 2023

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COVID-19: Maternal deaths in the tertiary health care center

Smruthi,

Rekha,

Manjula

et al. 2023

RHW

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The maternal mortality rate is increasing due to associated complications of labor, the severity of infection, and co-morbidities. The impact of COVID-19 infection on pregnant women data is insufficient in the literature, so in the present study, we are evaluating the rate of maternal mortality due to COVID-19 infection in McGANN Teaching District Hospital a tertiary health care center.The objective: to evaluate the rate of maternal mortality due to COVID-19 infection.Materials and methods. This is a single-center retro-prospective study, which included all maternal mortalities with COVID-19 infection admitted to the department of obstetrics and gynecology, McGANN teaching district hospital a tertiary health care center from June 2020 to October 2021. COVID-19 infected 15 pregnant women who died during hospitalization, treatment, labor, and after labor due to various complications. Data were collected from the medical record section and presented in an excel sheet and analyzed using SPSS software.Results. In the study period, maternal mortality due to COVID-19 infection was found to be more in the less than 30 years age group (73.3 %). Nearly all cases were admitted with complaints of fever (40 %), cough (53.3 %), abdominal pain (13.3 %), and breathlessness (80 %). Out of 15 maternal deaths, most of the cases are found to be primiparous (46.7 %), and the time from delivery to a death varies from 1-14 days. Nearly 66.7 % of cases had a gestational period of fewer than 36 weeks. Pulse rate, respiration rate, inflammatory markers, prothrombin time, liver enzymes, and blood glucose levels were elevated. The total protein hemoglobin and oxygen saturation percentage declined in the cases. The known co-morbidity present in the cases associated with maternal mortality was hypertension (20 %), diabetic mellitus (13.3 %), valvular heart disease (6.7 %), and pre-eclampsia (6.7 %). The most cause of death was acute respiratory distress syndrome (80 %).Conclusions. In this study the severe infection with co-morbidities showed an increased risk of severe morbidity and mortality.

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Perinatal Outcome in Maternal COVID-19 infection at a Tertiary care Institute- A cross Sectional Study

Cited by 2 publications

References 30 publications

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

Low Interferon-γ Levels in Cord and Peripheral Blood of Pregnant Women Infected with SARS-CoV-2

COVID-19: Maternal deaths in the tertiary health care center

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