Perinatal outcome of growth restricted fetuses with abnormal umbilical artery Doppler waveforms compared to growth restricted fetuses with normal umbilical artery Doppler waveforms at a tertiary referral hospital in urban Ethiopia

Tolu, Lemi Belay; Ararso, Roba; Abdulkadir, Abdulfetah; Feyissa, Garumma Tolu; Worku, Yoseph

doi:10.1371/journal.pone.0234810

Cited by 16 publications

(14 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mortality was not observed in any group. Tolu LB et al [9] showed 15 neonatal deaths in both the groups. 24% from those having abnormal Doppler scan and 4.5% from normal Doppler scan group.…”

Section: Discussionmentioning

confidence: 93%

A Prospective Observational Study Comparing Clinical Outcome of Iugr Neonates With Normal and Abnormal Umbilical Artery Flow Doppler

Panchal

Munshi²,

Chauhan

2020

Global Journal for Research Analysis

View full text Add to dashboard Cite

Background: Intrauterine growth restriction (IUGR) is one of the causes of perinatal mortality and morbidity which affects approximately 9.65% of pregnancies worldwide. Doppler indices from the fetal circulation can reliably predict adverse perinatal outcome. Aims &objectives: To compare perinatal complications and outcome between term and preterm IUGR neonates having normal and abnormal umbilical artery flow Doppler. Methodology: 140 IUGR Neonates with abnormal and normal antenatal umbilical artery Doppler scan admitted in NICU of Civil Hospital, Ahmedabad were included in the study. Amongst them 52 were preterm and 88 were term neonates. Study was conducted between October 2019 to December 2019. Primary outcome measure is neonatal mortality and secondary outcome measure is neonatal morbidities like perinatal asphyxia, hypoglycemia, NEC, hyperbilirubinemia etc. Results: Amongst140 IUGR neonates Preterm were more in case group 36(51.4%) compared to control group 16(22.8 %.) Hypoglycaemia and NEC was observed more in preterm 19 (36.5%) and 14(26.9%) compared to 16(18.2%) and 11(12.5%) in term respectively. Birth asphyxia was observed more in term 26(29.5%) than preterm 7(13.5%). At birth perinatal asphyxia was observed more in case group, 27 out of 70 (38.5%), as compared to 6 out of 70 (8.5%) in control group (P <0.05). Hypoglycemia and NEC was noticed in 30(42.8%) and 24(34.2%) neonates in case group, as compared to 5(7.1%) and 2(2.8%) neonates in control group respectively. (P < 0.05) Conclusion: Neonates with abnormal Umbilical Artery Doppler flow are at increased risk of perinatal complications and needs extra care during this period.

show abstract

Section: Discussionmentioning

confidence: 93%

A Prospective Observational Study Comparing Clinical Outcome of Iugr Neonates With Normal and Abnormal Umbilical Artery Flow Doppler

Panchal

Munshi²,

Chauhan

2020

Global Journal for Research Analysis

View full text Add to dashboard Cite

show abstract

“…Abnormal placentation is underlying pathology in pre-eclampsia and in it trophoblastic invasion of spiral arterioles is impaired and inadequate leading to increase resistance in uteroplacental circulation and decrease perfusion [4][5][6] . Preeclampsia is responsible for various adverse outcomes including prematurity, low birth weight, neonatal intensive care, intrauterine foetal death, foetal hypoxia, perinatal death 3 .…”

Section: Introductionmentioning

confidence: 99%

“…These changes in blood flow can be measured by non-invasive method i.e. Doppler ultrasound velocimetry and help to diagnose in-time foetal compromise so that timely intervention can be taken to decrease foetal morbidity and mortality 5,6 . The first application of doppler velocimetry in obstetrics was reported by Fitzgerald et al 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The blood flow characteristics can be quantified by doppler indices by systolic/diastolic (S/D) ratio= peak systolic velocity/end diastolic velocity, resistance index (RI=peak systolic velocity-end diastolic velocity/ peak systolic velocity), cerebroplacental index (CPI= MCA resistance/UmA resistance), pulsatility Index (peak systolic velocity-end diastolic velocity/mean velocity) 6,7 . Several studies have reported higher sensitivities and specificities for S/D ratio and CPI with umbilical artery velocimetry alone for prediction of the fetal prognosis 2 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Doppler Indices in the Prediction of Adverse Perinatal Outcome in Preeclampsia

Tabasam¹,

Malik

Siraj

et al. 2021

PAFMJ

View full text Add to dashboard Cite

Objective: To determine diagnostic accuracy of systolic/diastolic ratio and cerebro-placental index in predicting adverse perinatal outcome among patients in preeclampsia. Study Design: Cross-sectional validation study. Place and Duration of Study: Department of Obstetrics and Gynaecology, Pak Emirates Military Hospital, Rawalpindi, from Jun to Dec 2017. Methodology: A total of 191 patients with preeclampsia were included. Doppler ultrasound (including doppler wave forms obtained from free floating portion of umbilical artery and doppler waveform from middle cerebral artery at the level of circle of Willis) examination was done after gestational age 30 weeks and Doppler study repeated at 2-4 weeks interval depending on severity of preeclampsia and abnormalities of waveform. Cases were followed and results of last Doppler examination within 10 days of delivery were considered and perinatal outcome noted. Results: The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of systolic/diastolic ratio in predicting adverse perinatal outcome among patients in preeclampsia, keeping actual adverse perinatal outcome as reference standard was 82.35%, 86.52%, 87.50%, 81.05% and 84.29% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of cerebro-placental index in predicting adverse perinatal outcome among patients in preeclampsia, keeping actual adverse perinatal outcome as reference standard was 78.67%, 92.24%, 86.76%, 86.99% and 86.91% respectively. Conclusion: The diagnostic accuracy of systolic/diastolic ratio, cerebro-placental index in predicting adverse perinatal outcome among patients in preeclampsia is quite high.

show abstract

“…The optimal timing for delivery for IUGR affected pregnancies remains controversial. Sever fetal morbidities and deaths may be prevented by proper antenatal surveillance tests and timed delivery [9] .…”

Section: Introductionmentioning

confidence: 99%

Value of Middle Cerebral/Umbilical Artery Resistance Index Ratio in Neonatal Outcome in Patients with Intrauterine Growth Restriction (Prospective Study)

Aziz

Rady

Abdeltawab

2020

International Journal of Medical Arts

View full text Add to dashboard Cite

Background: Disorders related to intra-uterine fetal growth usually had different perinatal morbidity and mortality. Accurate diagnosis of intrauterine fetal growth is a challenging difficult task, but recent technological advances are associated with significant improvements with positive impact on antenatal care. Aim of the work: The aim of this study was to evaluate the accuracy of the umbilical and middle cerebral artery Doppler indices [e.g. resistance index] in prediction of fetal outcome in pregnancies with intra-uterine growth restriction (IUGR). Patients and Methods: Forty-five pregnant females had been included in a prospective study. All had a confirmed diagnosis of IUGR. Doppler ultrasound used to record fetal middle cerebral artery [MCA] and umbilical and Doppler indices every one week (from 32 weeks onwards). Post-delivery birth weight, Apgar score at 0 and 5 minutes had been measured and correlated with Doppler indices. Results: One-fifth of the mothers participating in the study (20%) had pre-term birth and 6.7% missed the follow-up. Umbilical artery resistance index (RI) at a cut off value of (0.79) had a diagnostic accuracy of 93%. MCA RI best cut off value was 0.63 with diagnostic accuracy of 73.9%. Also, for C/U ratio had diagnostic accuracy of 92.9%. Finally, there was significant, proportional correlation between MCA RA and C/U ratio from one side and APGAR score at 0 and 5 minutes from the other side. However, the correlation between UARI and Apgar score was inverse and statistically significant. Conclusion: Doppler velocimetry of fetal circulation can provide important information regarding fetal well-being, with subsequent impact on fetal outcome.

show abstract

Perinatal outcome of growth restricted fetuses with abnormal umbilical artery Doppler waveforms compared to growth restricted fetuses with normal umbilical artery Doppler waveforms at a tertiary referral hospital in urban Ethiopia

Cited by 16 publications

References 17 publications

A Prospective Observational Study Comparing Clinical Outcome of Iugr Neonates With Normal and Abnormal Umbilical Artery Flow Doppler

A Prospective Observational Study Comparing Clinical Outcome of Iugr Neonates With Normal and Abnormal Umbilical Artery Flow Doppler

Role of Doppler Indices in the Prediction of Adverse Perinatal Outcome in Preeclampsia

Value of Middle Cerebral/Umbilical Artery Resistance Index Ratio in Neonatal Outcome in Patients with Intrauterine Growth Restriction (Prospective Study)

Contact Info

Product

Resources

About