Perinatal transmission of hepatitis B virus: could hospitals be doing more?

Zhang, Fu-Kui; Zhang, Ying

doi:10.1586/eri.10.55

Cited by 3 publications

(2 citation statements)

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“…Acute hepatitis E is the major cause of a wide range of liver diseases in Bangladesh, ranging from severe acute viral hepatitis to fulminant hepatic failure and decompensation of liver cirrhosis [4]. Pregnant women with jaundice and acute viral hepatitis caused by HEV infection had a higher maternal mortality rate and worse obstetric and fetal outcomes than pregnant women with jaundice and acute viral hepatitis caused by other types of hepatitis viruses [5].…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Acute Viral Hepatitis A, B, C, and E in Pregnant Women Presenting to Hayatabad Medical Complex, Peshawar, Pakistan

Khan¹,

Waqar²,

Rafiq³

et al. 2022

Cureus

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To determine the frequency of hepatitis A, B, C, and E viruses (HAV, HBV, HCV, HEV) in pregnant women with acute hepatitis presenting to the medical units of HMC, Peshawar. MethodsThis is a descriptive cross-sectional study in which 442 pregnant women, either multi or primigravida, with yellow discolouration of the sclerae of the eyes and elevated alanine aminotransferase (ALT) > 100 U/L on laboratory tests were chosen by convenience (non-probability) sampling to assess the frequency of HAV, HBV, HCV, HEV. ResultsThe majority, i.e., 58.8%, were in the age range of >30 years and presented in the third trimester. Of the subjects, 81.90% had parity in the range of 1-5, 89.4% were multigravida, 71.3% were illiterate, and 73.1% were in the low-income category. Anti-HEV was detected in 47.3% of pregnant women, Anti-HCV in 30.3%, Hepatitis B surface antigen (HBsAg) in 11.5%, Hepatitis A-IgM in 5%, and 5.90% of the cases were virus-free. ConclusionsHBV, HCV, and HEV exposure, in particular, may have a substantially larger impact on pregnancy and neonatal outcomes than HAV. As a result, at the first prenatal appointment, standard viral hepatitis screening in pregnant women may need to be reviewed.

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Section: Introductionmentioning

confidence: 99%

“…Vertical transmission cannot be prevented because there is no HCV vaccination or approved drug for use during pregnancy. Due to a low vertical transmission rate of 3-5%, a high rate of spontaneous clearance (25-50%), and delayed morbidity, HCV has been overlooked in pregnant women and their babies [5].…”

Section: Introductionmentioning

confidence: 99%