2017
DOI: 10.4081/ni.2017.6933
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Periodic lateralized epileptiform discharges can survive anesthesia and result in asymmetric drug-induced burst suppression

Abstract: Drug-induced burst suppression (DIBS) is bihemispheric and bisymmetric in adults and older children. However, asymmetric DIBS may occur if a pathological process is affecting one hemisphere only or both hemispheres disproportionately. The usual suspect is a destructive lesion; an irritative or epileptogenic lesion is usually not invoked to explain DIBS asymmetry. We report the case of a 66-year-old woman with new-onset seizures who was found to have a hemorrhagic cavernoma and periodic lateralized epileptiform… Show more

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Cited by 3 publications
(2 citation statements)
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“…Spike frequencies were similar to those reported for discharges in lateralized periodic discharges (LPDs), which were described to arise in the terminal phase of SE in humans [127]. Besides SE, LPDs (formerly known as PLEDs: periodic lateralized epileptiform discharges [128]) have been associated with stroke, traumatic brain injury, tumors and encephalitis, i.e., acute and chronic brain lesions widely recognized as pathologies potentially leading to epilepsy [129]. LPDs and IIS share etiological (e.g., association with SE [127,130] and morphological (interictal spike-like contributions [129]) aspects, and there are also pharmacological (resistance to anti-epileptic drug treatment [129,131]) and further pathological similarities (e.g., cognitive dysfunction [132,133]) between these two.…”
Section: Role In Epilepsy/epileptogenesissupporting
confidence: 53%
See 1 more Smart Citation
“…Spike frequencies were similar to those reported for discharges in lateralized periodic discharges (LPDs), which were described to arise in the terminal phase of SE in humans [127]. Besides SE, LPDs (formerly known as PLEDs: periodic lateralized epileptiform discharges [128]) have been associated with stroke, traumatic brain injury, tumors and encephalitis, i.e., acute and chronic brain lesions widely recognized as pathologies potentially leading to epilepsy [129]. LPDs and IIS share etiological (e.g., association with SE [127,130] and morphological (interictal spike-like contributions [129]) aspects, and there are also pharmacological (resistance to anti-epileptic drug treatment [129,131]) and further pathological similarities (e.g., cognitive dysfunction [132,133]) between these two.…”
Section: Role In Epilepsy/epileptogenesissupporting
confidence: 53%
“…Besides SE, LPDs (formerly known as PLEDs: periodic lateralized epileptiform discharges [128]) have been associated with stroke, traumatic brain injury, tumors and encephalitis, i.e., acute and chronic brain lesions widely recognized as pathologies potentially leading to epilepsy [129]. LPDs and IIS share etiological (e.g., association with SE [127,130] and morphological (interictal spike-like contributions [129]) aspects, and there are also pharmacological (resistance to anti-epileptic drug treatment [129,131]) and further pathological similarities (e.g., cognitive dysfunction [132,133]) between these two. Hence, considering the close association between LPDs and brain insult, a narrow time window for interference with potentially epileptogenic discharges [134] may also apply to the situation in humans.…”
Section: Role In Epilepsy/epileptogenesismentioning
confidence: 99%