Periodontal disease and type 1 diabetes mellitus: Associations with glycemic control and complications: An Indian perspective

Meenawat, Ajita; Punn, Karan; Govila, Vivek; Anand, Shomi; Maheshwari, Anuj

doi:10.1016/j.dsx.2013.03.001

Cited by 17 publications

(10 citation statements)

References 14 publications

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“…Chronic periodontitis (ChP), an inflammatory disease that affects 46% of US adults (Eke et al 2015), is initiated by dysbiotic bacteria that activate the host’s local immune response, thereby destroying connective tissue and bone, forming periodontal pockets, and eventually causing tooth loss. Accumulating epidemiologic evidence also supports a strong association between ChP and systemic diseases, including cardiovascular disease, diabetes, Alzheimer’s disease, malignancies, and adverse pregnancy outcomes (Bassani et al 2007; Conde-Agudelo et al 2008; Nabet et al 2010; Ajita et al 2013; Morishita et al 2013; Nguyen et al 2015; Peng et al 2017). Demonstrating a mechanistic link between ChP and adverse health outcomes is critical for implementation of effective strategies to prevent ChP and its negative health consequences.…”

Section: Introductionmentioning

confidence: 91%

Systemic Immunologic Consequences of Chronic Periodontitis

et al. 2019

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Chronic periodontitis (ChP) is a prevalent inflammatory disease affecting 46% of the US population. ChP produces a profound local inflammatory response to dysbiotic oral microbiota that leads to destruction of alveolar bone and tooth loss. ChP is also associated with systemic illnesses, including cardiovascular diseases, malignancies, and adverse pregnancy outcomes. However, the mechanisms underlying these adverse health outcomes are poorly understood. In this prospective cohort study, we used a highly multiplex mass cytometry immunoassay to perform an in-depth analysis of the systemic consequences of ChP in patients before ( n = 28) and after ( n = 16) periodontal treatment. A high-dimensional analysis of intracellular signaling networks revealed immune system–wide dysfunctions differentiating patients with ChP from healthy controls. Notably, we observed exaggerated proinflammatory responses to Porphyromonas gingivalis–derived lipopolysaccharide in circulating neutrophils and monocytes from patients with ChP. Simultaneously, natural killer cell responses to inflammatory cytokines were attenuated. Importantly, the immune alterations associated with ChP were no longer detectable 3 wk after periodontal treatment. Our findings demarcate systemic and cell-specific immune dysfunctions in patients with ChP, which can be temporarily reversed by the local treatment of ChP. Future studies in larger cohorts are needed to test the boundaries of generalizability of our results.

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Section: Introductionmentioning

confidence: 91%

Systemic Immunologic Consequences of Chronic Periodontitis

et al. 2019

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“…Curiously, a study evaluating the impact of hypoglycemic therapy on periodontal tissues revealed that the reduction of HbA1c levels over the six months period improved bleeding on probing (BOP) without periodontal therapy [18]. Furthermore, numerous studies showed that poor glycemic control is associated to a greater risk of developing severe periodontitis compared to well-controlled subjects with diabetes [19][20][21][22][23].…”

Section: Diabetes and Its Impact On Periodontal Healthmentioning

confidence: 99%

Impact of Periodontitis on Glycemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Therapeutic Perspectives

Santonocito

Polizzi

Marchetti

et al. 2022

Mediators of Inflammation

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Diabetes mellitus and periodontitis are two of the most common chronic diseases affecting the world’s population, and they are intimately linked. For several years, in fact, it has been known that there is an interdependent relationship between the two diseases: Diabetes promotes the destruction of periodontal tissues, and periodontal disease negatively affects glycemic control. In relation to the control of dental plaque and oral dysbiosis responsible for periodontal disease, both nonsurgical and surgical therapy associated with proper home hygiene procedures have emerged as essential for good glycemic control. Moreover, several evidences suggest the essential role played by the control of periodontal disease in preventing the onset of the most common complications of diabetes: cardiovascular diseases, retinopathies, and other systemic diseases. The aim of this study is to update the current knowledge on the bi-univocal relationship between diabetes and periodontitis and the impact of therapy in the optimal management of these two disorders. From the information found in the literature, it has emerged that the correct treatment of periodontal disease in diabetic patients represents one of the main mechanisms and means currently established and valid to control periodontal disease and glucose metabolism and prevent the onset or development of diabetic complications.

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“…Conventional treatment of diabetes (especially type 2) involves changing habits, such as diet control and physical activity. Eventually, some patients need to use oral hypoglycemic agents and/or insulin, depending on the severity of the disease [ 9 , 10 ]. Studies investigating the effects of regular physical activity on diabetic patients with periodontal disease are scarce, especially when inflammatory and metabolic aspects are evaluated simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

et al. 2018

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The authors aimed to evaluate the effects of physical exercise on the metabolism and progression of periodontal disease (PD), induced by ligature in diabetic rats induced by high fat diet and streptozotocin (HFD/STZ). Diabetes Mellitus (DM) was induced by four weeks of a hyperlipidic diet associated with a single low-dose of streptozotocin (35 mg/kg/animal). The exercise groups swam for 60 min/day for eight weeks (five times/week). In the last two weeks of exercise, a ligature was placed around the right and left mandibular first molars. The authors determined alveolar bone loss by morphometry. Blood biochemical profile and serum levels of IL-10 and TNF-α were evaluated by colorimetric and enzyme-linked immunosorbent assays (ELISA), respectively. The diabetic animals subjected to exercise showed decreased alveolar bone loss, lower glycemia, triacylglycerols and glycosylated hemoglobin levels than the controls. Total cholesterol and its fractions (High density lipoprotein—HDL-c, Low density lipoprotein—LDL-c and Very low density lipoprotein—VLDL-c) remained similar among the groups. Animals with PD showed higher levels of TNF-α and lower levels of IL-10, when compared to animals without PD. In diabetic animals with PD, physical exercise decreased TNF-α levels and increased IL-10 levels as well as the IL10/TNF-α ratio. In conclusion, eight weeks of physical exercise improved glycemic control and systemic inflammatory profile, and attenuated alveolar bone loss in rats with DM and PD.

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Periodontal disease and type 1 diabetes mellitus: Associations with glycemic control and complications: An Indian perspective

Cited by 17 publications

References 14 publications

Systemic Immunologic Consequences of Chronic Periodontitis

Systemic Immunologic Consequences of Chronic Periodontitis

Impact of Periodontitis on Glycemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Therapeutic Perspectives

Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

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