Periodontal disease might be associated even with impaired fasting glucose

Zadik, Yehuda; Bechor, Ron; Galor, Shay; Levin, Liran

doi:10.1038/sj.bdj.2010.291

Cited by 38 publications

(42 citation statements)

References 21 publications

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“…A few studies suggested that periodontal disease was positively associated with impaired glucose tolerance or impaired fasting glucose (IFG), 18–20 but other studies found no association between periodontal disease and impaired glucose tolerance. 21,22 Furthermore, there has been little research on the prevalence of periodontitis between individuals with prediabetes and diabetes, as well as in the overall population, using nationally representative data.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults

2016

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Although the relationship between diabetes and periodontitis is well established, the association between periodontitis and prediabetes has been investigated less extensively. Furthermore, there has been little research on the prevalence of periodontitis among individuals with prediabetes and diabetes as well as in the overall population using nationally representative data.Among 12,406 adults (≥19 years’ old) who participated in the 2012–2013 Korea National Health and Nutrition Examination Survey, a total of 9977 subjects completed oral and laboratory examinations and were included in this analysis. Periodontitis was defined as a community periodontal index score of ≥3 according to the World Health Organization criteria. The fasting plasma glucose level was categorized into the following 5 groups: normal fasting glucose (NFG) 1 (<90 mg/dL), NFG 2 (90–99 mg/dL), impaired fasting glucose (IFG) 1 (100–110 mg/dL), IFG 2 (111–125 mg/dL), and diabetes (≥126 mg/dL).Overall, the weighted prevalence of periodontitis among the Korean adult population was 24.8% (23.3–26.4%) (weight n = 8,455,952/34,086,014). The unadjusted weighted prevalences of periodontitis were 16.7%, 22.8%, 29.6%, 40.7%, and 46.7% in the NFG 1, NFG 2, IFG 1, IFG 2, and diabetes groups, respectively (P < 0.001). After adjusting for age, sex, smoking history, heavy alcohol drinking, college graduation, household income, waist circumference, serum triglyceride level, serum high-density lipoprotein cholesterol level, and the presence of hypertension, the adjusted weighted prevalence of periodontitis increased to 29.7% in the IFG 2 group (P = 0.045) and 32.5% in the diabetes group (P < 0.001), compared with the NFG 1 group (24%). The odds ratios for periodontitis with the above-mentioned variables as covariates were 1.42 (95% confidence interval [CI] 1.14–1.77, P = 0.002) in the diabetes group and 1.33 (95% CI 1.01–1.75, P = 0.044) in the IFG 2 group, respectively, compared with the NFG1 group.In conclusion, a higher range of IFG levels as well as diabetes, were positively associated with chronic periodontitis in a representative sample of Korean adults. This study suggests that individuals with a higher range of IFG levels before diabetes are at risk of periodontitis, and may benefit from dental screening.

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Section: Introductionmentioning

confidence: 99%

The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults

2016

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“…In addition, further study assessed the relationship between impaired fasting glucose (IFG) and chronic periodontitis [20]. Recent study has revealed that periodontitis prevalence is proportional to the HOMA-IR in women at post-menopausal status, although this type of link was not found in men and pre-menopausal women in Korean adults [21].…”

Section: Clinicalmentioning

confidence: 99%

Association of periodontitis with insulin resistance, β-cell function, and impaired fasting glucose before onset of diabetes

et al. 2015

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“…It has been shown that nondiabetic patients with periodontal disease demonstrate impaired glycaemic control as well as having higher BMIs (body mass indexes) and higher LDL (low-density lipoprotein)-cholesterol, triacylglycerol (triglyceride) and total cholesterol levels [26].…”

Section: Periodontitis and Its Relationship With Dmmentioning

confidence: 99%

The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

Lazenby

Crook

2010

Clinical Science

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About a decade ago, a hypothesis was proposed suggesting that the innate immune system, including acute-phase reactants, contribute to the development of T2DM [Type 2 DM (diabetes mellitus)] and the metabolic syndrome. In this model, it was hypothesized that the innate immune system modulates the effects of many factors, including genes, fetal programming, nutrition and aging, upon the later development of metabolic problems associated with insulin resistance. In this present article, we expand this hypothesis by looking at the involvement of periodontitis in DM and its complications. Periodontitis is a common inflammatory process involving the innate immune system and is associated with DM. We will also illustrate how dental disease is important in patients with DM and could be implicated in various diabetic complications.

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Periodontal disease might be associated even with impaired fasting glucose

Cited by 38 publications

References 21 publications

The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults

The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults

Association of periodontitis with insulin resistance, β-cell function, and impaired fasting glucose before onset of diabetes

The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

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Periodontal disease might be associated even with impaired fasting glucose

Cited by 38 publications

References 21 publications

The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults

The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults

Association of periodontitis with insulin resistance, &beta;-cell function, and impaired fasting glucose before onset of diabetes

The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

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Association of periodontitis with insulin resistance, β-cell function, and impaired fasting glucose before onset of diabetes