Periosteal and Perichondral Grafting in Reconstructive Surgery

Ritsilä, Veijo; Santavirta, Seppo; Alhopuro, S; Poussa, Mikko; Jaroma, H; Rubak, Jens M.; Eskola, Antti; Hoikka, Veijo; Snellman, O; Osterman, K

doi:10.1097/00003086-199405000-00040

Cited by 119 publications

(72 citation statements)

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“…45,48 Perichondral grafts have the capacity to generate cartilage. However, the differentiation of these cells into hyaline cartilage depends on extrinsic environmental factors.…”

Section: Effect Of the Local Environment On Chondral Healingmentioning

confidence: 99%

The Treatment of Articular Cartilage Defects Using the Microfracture Technique

Gill

Asnis²,

Berkson³

2006

J Orthop Sports Phys Ther

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Chondral defects of the articular surface pose a challenging problem to the orthopedic surgeon. The goal of surgery is to alleviate pain, maximize function, and prevent degenerative changes in the future. A number of techniques have been described to treat these lesions. When considering the treatment options for chondral defects, the surgeon must consider the size, depth, location, and chronicity of the lesion. In addition, the overall alignment of the joint must be evaluated. Prior to treating chondral defects, it is important to understand the indications and contraindica-tions for the microfracture technique. When indicated, the microfracture technique has many advantages over other surgical options. This technique is relatively easy to perform, cost effective, and has low patient morbidity. In addition, the microfracture technique does not burn any long-term bridges, enabling the surgeon to choose a different procedure to revise the chondral defect if the microfracture fails. It is important to understand the mechanism of healing by microfracture, including the effects of the local environment. The postoperative protocol used after the procedure may be as important as the surgery itself. Understanding the science behind the microfracture procedure will lead to better surgical technique and improved outcomes. J Orthop Sports Phys Ther 2006;36(10):728-738. doi:10.2519/jospt.2006.244

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“…45,48 Perichondral grafts have the capacity to generate cartilage. However, the differentiation of these cells into hyaline cartilage depends on extrinsic environmental factors.…”

Section: Effect Of the Local Environment On Chondral Healingmentioning

confidence: 99%

The Treatment of Articular Cartilage Defects Using the Microfracture Technique

Gill

Asnis²,

Berkson³

2006

J Orthop Sports Phys Ther

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“…However, this procedure remains to be technically difficult and can result in variable patient outcomes based on differences in the height of the defect cartilage and the surrounding native cartilage as well as the accumulation of fibrocartilage within the gaps regions between the transplanted plugs [17,18]. For the repair of chondral defects, other implantation treatment methods involve grafting strips of perichondrium [19] or periosteum [20][21][22] to the defect using fibrin glue. In the case of periosteal grafts, the problem of graft calcification can occur over time.…”

Section: Tissue Implantationmentioning

confidence: 99%

Nanomaterials for cartilage tissue engineering

Chiu¹,

Waldman²

2016

Nanomaterials and Regenerative Medicine

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“…These characteristics make autologous periosteal transplantation a viable method for treating cartilage defects. This procedure is used clinically to treat patients [1,18,23,24,30,45], and is also used experimentally in animals [26,28,32,33,46,49]. The main limitation of this procedure is the variability in cartilage produced by the transplanted periosteum.…”

Section: Introductionmentioning

confidence: 99%

Induction of CD‐RAP mRNA during periosteal chondrogenesis

Sanyal

Clemens

Fitzsimmons

et al. 2003

Journal Orthopaedic Research

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Induction of chondrogenesis and maintenance of the chondrocyte phenotype are critical events for antologous periosteal transplantation, which is a viable approach for cartilage repair. Cartilage-derived retinoic acid-sensitive protein (CD-RAP) is a recently discovered protein that is mainly produced in cartilage. During development, CD-RAP expression starts at the beginning of chondrogenesis and continues throughout cartilage maturation. In order to investigate the involvement of CD-RAP during periosteal chondrogenesis we have determined the nucleotide sequence of the rabbit CD-RAP mRNA and utilized this information to evaluate the temporal and spatial expression pattern of CD-RAP at the mRNA level during chondrogenesis. When the periosteal explants were cultured under chondrogenic conditions, the expression of CD-RAP was induced, as shown by a 40-fold increase in CD-RAP mRNA between days 7 and 10. The temporal expression pattern of CD-RAP closely mimicked that of collagen type IIB mRNA. Also, the CD-RAP mRNA was localized to the matrix forming chondrocytes in the cambium layer of the periosteum by in situ hybridization as indicated by colocalization with collagen type TI mRNA and positive safranin 0 staining. These data suggest a regulatory role of CD-RAP in periosteal chondrogenesis, which is potentially important for both cartilage repair and fracture healing via callus formation.

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Periosteal and Perichondral Grafting in Reconstructive Surgery

Cited by 119 publications

References 0 publications

The Treatment of Articular Cartilage Defects Using the Microfracture Technique

The Treatment of Articular Cartilage Defects Using the Microfracture Technique

Nanomaterials for cartilage tissue engineering

Induction of CD‐RAP mRNA during periosteal chondrogenesis

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