Peripheral catecholamine alterations in adolescents with polycystic ovary syndrome

Garcia-Rudaz, Cecilia; Armando, Inés; Levin, Gloria; Escobar, María Eugenia; Barontini, Marta

doi:10.1046/j.1365-2265.1998.00511.x

Cited by 40 publications

(29 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data confirmed earlier studies conducted on human and rat cystic ovaries [10,[25][26][27]. An increase in the number of studied nerve t e r m i n a l s a r o u n d c y s t s a n d f o l l i c l e s w a s accompanied by an increase in the amount of NA in the cystic fluid and walls, and in the amount of NA and A in the walls of small and medium-sized follicles.…”

Section: Discussionsupporting

confidence: 82%

Dexamethasone-induced Changes in Sympathetic Innervation of Porcine Ovaries and in Their Steroidogenic Activity

Jana

Dzienis

Rogozinska

et al. 2005

Journal of Reproduction and Development

View full text Add to dashboard Cite

Abstract. The aim of the present study was to determine changes in the density of sympathetic nerves in porcine ovaries with dexamethasone (DXM)-induced cysts and the alterations in steroidogenic activity and amounts of catecholamines in the affected gonads. Cystic ovaries were supplied by numerous sympathetic nerve fibers. The amount of noradrenaline in the cysts (fluid, wall) was significantly higher than in the large follicles of the control group. After DXM injections, the amounts of noradrenaline and adrenaline significantly increased in the walls of small and medium-sized follicles. In the cysts (fluid, wall) the levels of androgens and estrogens were significantly lower, whereas progesterone was higher in the cystic wall. DXM administration led to a significant increase in the estrone content in the fluid of small follicles. Moreover, a decrease in the amounts of progesterone and androgens was found in the follicular fluid and walls of medium-sized follicles. DXM injections resulted in a significant increase in the immunoexpression of P450scc and 3β-HSD in the cysts, a significant increase of P450scc in the follicles, and a decrease of 3β-HSD and P450arom. The present study shows that the DXM treatment leads to an increase in the density of intraovarian sympathetic nerves, paralleled by the amount of catecholamines, and that it is capable of changing the steroidogenic activity of porcine ovary bearing cysts. Thus, it appears possible that these events may be, at least partly, involved in the pathogenesis of this disorder.

show abstract

Section: Discussionsupporting

confidence: 82%

Dexamethasone-induced Changes in Sympathetic Innervation of Porcine Ovaries and in Their Steroidogenic Activity

Jana

Dzienis

Rogozinska

et al. 2005

Journal of Reproduction and Development

View full text Add to dashboard Cite

show abstract

“…In support of our findings, women with PCOS have greater density of ovarian cathecholaminergic nerve fibers (27,53), altered catecholamine metabolism (18), and disturbed HRV (81) and abnormal heart rate recovery (HRR) after exercise test, two indirect markers of autonomic function (20,67,71). Furthermore, PCOS is associated with risk factors thought to be related to altered activity of the sympathetic nervous system, such as hyperinsulinemia, insulin resistance, obesity, and cardiovascular disease (20,31,67,72).…”

Section: Pcos Is Associated With High Sympathetic Nerve Activitysupporting

confidence: 58%

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

Stener-Victorin¹,

Jedel²,

Janson³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

150

166

View full text Add to dashboard Cite

Stener-Victorin E, Jedel E, Janson PO, Sverrisdottir YB. Lowfrequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol 297: R387-R395, 2009. First published June 3, 2009 doi:10.1152/ajpregu.00197.2009We have recently shown that polycystic ovary syndrome (PCOS) is associated with high muscle sympathetic nerve activity (MSNA). Animal studies support the concept that low-frequency electroacupuncture (EA) and physical exercise, via stimulation of ergoreceptors and somatic afferents in the muscles, may modulate the activity of the sympathetic nervous system. The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with PCOS. In a randomized controlled trial, 20 women with PCOS were randomly allocated to one of three groups: low-frequency EA (n ϭ 9), physical exercise (n ϭ 5), or untreated control (n ϭ 6) during 16 wk. Direct recordings of multiunit efferent postganglionic MSNA in a muscle fascicle of the peroneal nerve before and following 16 wk of treatment. Biometric, hemodynamic, endocrine, and metabolic parameters were measured. Low-frequency EA (P ϭ 0.036) and physical exercise (P ϭ 0.030) decreased MSNA burst frequency compared with the untreated control group. The low-frequency EA group reduced sagittal diameter (P ϭ 0.001), while the physical exercise group reduced body weight (P ϭ 0.004) and body mass index (P ϭ 0.004) compared with the untreated control group. Sagittal diameter was related to MSNA burst frequency (Rs ϭ 0.58, P Ͻ 0.005) in the EA group. No correlation was found for body mass index and MSNA in the exercise group. There were no differences between the groups in hemodynamic, endocrine, and metabolic variables. For the first time we demonstrate that low-frequency EA and physical exercise lowers high sympathetic nerve activity in women with PCOS. Thus, treatment with low-frequency EA or physical exercise with the aim to reduce MSNA may be of importance for women with PCOS. polycystic ovary syndrome; sympathetic nerve activity; testosterone; insulin resistance; metabolic syndrome; cardiovascular disease POLYCYSTIC OVARY SYNDROME (PCOS) is one of the most common female endocrine disorders affecting ϳ10% of women of reproductive age, and is strongly associated with hyperandrogenism and ovulatory dysfunction (8,46). PCOS increases the risk of metabolic disturbances such as abdominal obesity, hyperinsulinaemia, and insulin resistance, which can lead to type 2 diabetes, and dyslipidemia (8, 46), as well as hypertension which may lead to the development of other cardiovascular diseases (35).Despite extensive research, the primary etiology remains unknown, although both environmental and genetic factors are implicated (17). Existing evidence suggests the ovarian theca cells, the major source of androgen production and secretion (22) to play a key role in the etiology. Also, the hypothalamicpituitary axis (50) and defective insulin a...

show abstract

“…Therefore, the male/female difference in plasma HVA cannot be explained by the male/female difference in sex steroid milieus, although an inverse correlation between HVA and testosterone levels was found in the genetic male group at baseline. These results are in line with the findings that testosterone administration in healthy young men did not affect HVA levels (Hannan et al 1991), that women with polycystic ovary syndrome, which is associated with hyperandrogenism, have similar plasma levels of catecholamines and urinary levels of HVA as compared with female controls (Garcia-Rudaz et al 1998), and that estrogen administration to postmenopausal women did not affect urinary HVA levels (Lobo et al 1984). What mechanism may explain the sex difference in HVA?…”

Section: Discussionsupporting

confidence: 81%

The sex difference of plasma homovanillic acid is unaffected by cross-sex hormone administration in transsexual subjects

Giltay

Kho²,

Blansjaar³

et al. 2005

Journal of Endocrinology

View full text Add to dashboard Cite

There is a close relationship between the brain and the endocrine system. The brain expresses receptors for sex steroids and is capable of metabolizing these hormones. We explored (1) sex differences in homovanillic acid (HVA), a metabolite of the neurotransmitter dopamine, and (2) the effects of cross-sex steroid administration in transsexual subjects. First, we compared plasma HVA levels between 38 male and 34 female healthy volunteers (not using hormone replacement therapy) of a mean age of 72 years (range 65-84 years). Secondly, we measured plasma HVA levels in 15 male-to-female transsexuals treated with 100 µg ethinyl estradiol/day and 100 mg cyproterone acetate/day for 4 months, and in 17 femaleto-male transsexuals treated with testosterone esters (250 mg/2 weeks i.m. for 4 months). Plasma HVA levels were lower in elderly men than in elderly postmenopausal women (geometric mean 25·4 nmol/l (percentile (P) 10 4·9; P 90 69·8) vs 39·0 nmol/l (19·0; 76·1); P=0·027). In transsexuals before cross-sex hormone administration, genetic males also had lower plasma levels of HVA than genetic females (geometric mean 14·8 nmol/l (P 10 7·0; P 90 35·0) vs 34·3 nmol/l (21·8; 61·4); P<0·001). Cross-sex hormone administration did not affect plasma HVA in either group (P>0·5). The pretreatment sex difference in plasma HVA was unaffected after 4 months of cross-sex hormone administration (P=0·003). The sex difference in plasma HVA was not reversed by cross-sex hormone administration in transsexuals, and was also preserved in elderly subjects. This indicated that differences in dopamine gene expression were largely unaffected by exposure to sex hormone levels in adulthood, but must rather be explained by a sex difference in genetic factors or by the organizing effects of sex hormones during early development.

show abstract

Peripheral catecholamine alterations in adolescents with polycystic ovary syndrome

Cited by 40 publications

References 38 publications

Dexamethasone-induced Changes in Sympathetic Innervation of Porcine Ovaries and in Their Steroidogenic Activity

Dexamethasone-induced Changes in Sympathetic Innervation of Porcine Ovaries and in Their Steroidogenic Activity

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

The sex difference of plasma homovanillic acid is unaffected by cross-sex hormone administration in transsexual subjects

Contact Info

Product

Resources

About