Peripheral Neuropathy in Chronic Obstructive Lung Disease

Moore, Nicholas; Lerebours, Guy; Sénant, J; Ozenne, G.; David, Pierre; Nouvet, G

doi:10.1016/s0140-6736(85)91599-5

Cited by 16 publications

(10 citation statements)

References 4 publications

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“…In the present study peripheral neuropathy has occurred at an incidence of 44.4% in patients with COPD.The prevalence of PN among COPD patients showed wide variety in previous studies (5% to 100% ) [4,5,16,18,[20][21][22][23][24][25][26]. In line with the previous studies, the distribution and types of neuropathic parameters mostly indicated involvement of lower extremities and manifestation as sensorial NP [4,20,23,24].…”

Section: Discussionsupporting

confidence: 86%

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

Ogan

Sayın

Baha

et al. 2019

The European Research Journal

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Objective: Chronic Obstructive Pulmonary Disease (COPD) is accompanied by several concomitant conditions due to its systemic effects. Hypoxia and oxidative stress associated with COPD are also believed to contribute to the disease course through the effects of several inflammatory mediators. Major causative agents causing of peripheral neuropathy are age, hypoxia, duration and severity of COPD, hypercapnia and smoking. The present study aimed to investigate the incidence of polyneuropathy and its relation with disease parameters in COPD patients. Methods: Of a total number of 45 patients who had been followed up between January 1, 2015 and December 31, 2016 with a diagnosis of COPD at Ufuk University School of Medicine were enrolled retrospectively. All patients underwent electroneuromyography, arterial blood gas measurements and pulmonary function tests. Patients were divided as those with or without neuropathy, and factors contributing to the development of neuropathy were investigated based on clinical and laboratory findings. Results: Eleven (24.4%) patients were women and 34 (74.6%) were men, and the mean age was 73.2 years. Mean PaO2 was 58.2 mmHg, pCO2 was 41.2 mmHg, and FEV1 was 45.3%. Neuropathy was diagnosed in twenty (44.4%) patients. Significant differences were found in pO2, pCO2, SO2, mMRC, smoking status and number of exacerbations per year (p < 0.05). Conclusions: Patients who experience frequent exacerbations and those with hypoxemia or hypercapnia as demonstrated should be taken into more careful clinical assessments with respect to polyneuropathy.

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Section: Discussionsupporting

confidence: 86%

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

Ogan

Sayın

Baha

et al. 2019

The European Research Journal

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“…In those studies, COPD patients of mild and moderate severity were evaluated using limited brainstem auditory evoked potential (BAEP) parameters and no significant changes were reported. Several studies have reported a subclinical peripheral neuropathy in COPD patients exposed to chronic hypoxaemia 3–6 …”

Section: Introductionmentioning

confidence: 99%

The brainstem auditory evoked potential abnormalities in severe chronic obstructive pulmonary disease

Atış¹,

Özge

Sevi.M

2001

Respirology

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“…In previous studies, the incidence of clinical or subclinical PNP in COPD has been reported as 28%–95%. 4 – 6 , 11 , 12 Faden et al found PNP incidence of 87% and Moore et al 58%. Similarly to the current study, both sensorial and motor abnormalities were detected in these studies.…”

Section: Discussionmentioning

confidence: 97%

“…Similarly to the current study, both sensorial and motor abnormalities were detected in these studies. 11 , 12 Kayacan et al found PNP incidence of 93.8% in a COPD group and a significant increase in conduction velocities of median and peroneal motor nerves when compared to a control group, but no difference was observed in the conduction velocities of the median sensorial nerve. 4 However, Narayan et al found a threefold-higher incidence of median sensory-nerve, median motor-nerve, and peroneal motor-nerve abnormalities in hypoxic patients.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease

Aras

Aydemir

Güngen

et al. 2018

COPD

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BackgroundThe aim of the study was to investigate the frequency and characteristics of peripheral nervous system (PNS) and central nervous system (CNS) involvement in COPD.MethodsThe study included 41 COPD patients and 41 healthy volunteers. Electrophysiological studies were carried out: electromyography (EMG) and visual evoked potentials (VEPs). The median nerve, ulnar nerve, common peroneal nerve, and tibial nerve were evaluated for latency, amplitude, and conduction velocity.ResultsThe mean age of patients with COPD was 61.8 years and disease duration 10.3 years. There was no difference between patient and control groups in terms of age, BMI, smoking status, or biochemical parameters. Upon VEP examination, latencies were significantly prolonged and amplitudes shortened in the patient group compared to the control group. In EMG measurements, conduction velocity and amplitudes in all nerves were low in the patient group. Similarly, latencies in all nerves were higher in patients with COPD.ConclusionCentral and peripheral nervous system involvement could develop in patients with moderate–severe COPD, and these patients should be monitored for neuropathic changes in combination with neurological examination.

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Peripheral Neuropathy in Chronic Obstructive Lung Disease

Cited by 16 publications

References 4 publications

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

The incidence of polyneuropthy and its relation with disease parameters in chronic obstructive pulmonary disease

The brainstem auditory evoked potential abnormalities in severe chronic obstructive pulmonary disease

Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease

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