Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats

Teixeira, Juliana Maia; Abdalla, Henrique Ballassini; Basting, Rosanna Tarkany; Hammock, Bruce D.; Napimoga, Marcelo Henrique; Clemente‐Napimoga, Juliana Trindade

doi:10.1016/j.intimp.2020.106841

Cited by 19 publications

(12 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LOX/autoxidation and sEH pathways are typically upregulated during inflammation (Patwardhan et al, 2010;Trindade-da-Silva et al, 2020;Warner et al, 2017), and inhibition of 5-LOX and sEH has been shown to halt and resolve inflammation (Fredman et al, 2014;Hiesinger et al, 2020;Liu et al, 2021;Teixeira et al, 2020;Yang et al, 2015). In this study, TRAP exposure dampened LOX/autoxidation and sEH pathways despite increasing proinflammatory cytokines (Edwards et al, 2020).…”

Section: Discussionmentioning

confidence: 62%

“…Conversely, CYP-derived epoxides of AA (i.e. epoxyeicosatrienoic acids (EpETrEs)), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as 15-LOX-1 hydroxylated metabolites of EPA and DHA are pro-resolving (Hasegawa et al, 2017;Rao et al, 2019;Teixeira et al, 2020;Wagner et al, 2017;Werz et al, 2018). These pro-resolving oxylipins act via specialized receptors (Reviewed in (Chiang and Serhan, 2017)) to stop and resolve inflammation by promoting cellular repair and phagocytosis of dead cells and debris (Kohli and Levy, 2009;Lahvic et al, 2018;Serhan and Levy, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

Liang

Emami

Patten

et al. 2022

Environmental Toxicology and Pharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

Liang

Emami

Patten

et al. 2022

Environmental Toxicology and Pharmacology

View full text Add to dashboard Cite

“…In albumin-induced rat temporomandibular joint arthritis model, pretreatment with TPPU inhibited the hypernociception and leukocyte migration. These protective effects were associated with decreased inducible nitric oxide synthase (iNOS) expression, reduced pro-inflammatory cytokine and upregulated anti-inflammatory cytokine [161]. Similarly, sEH inhibitor reduced the hyperalgesia induced by inflammation in the early-and post-inflammatory phase in K/BxN mouse model of arthritis [162].…”

Section: The Anti-inflammatory Effects Of Eets In Arthritismentioning

confidence: 99%

CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators

Shi¹,

Wang

2022

Molecules

View full text Add to dashboard Cite

Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs), which are merely biologically active. EETs possess a wide range of established protective effects on many systems of which anti-inflammatory actions have gained great interest. EETs attenuate vascular inflammation and remodeling by inhibiting activation of endothelial cells and reducing cross-talk between inflammatory cells and blood vessels. EETs also process direct and indirect anti-inflammatory properties in the myocardium and therefore alleviate inflammatory cardiomyopathy and cardiac remodeling. Moreover, emerging studies show the substantial roles of EETs in relieving inflammation under other pathophysiological environments, such as diabetes, sepsis, lung injuries, neurodegenerative disease, hepatic diseases, kidney injury, and arthritis. Furthermore, pharmacological manipulations of the AA-CYP450-EETs-sEH pathway have demonstrated a contribution to the alleviation of numerous inflammatory diseases, which highlight a therapeutic potential of drugs targeting this pathway. This review summarizes the progress of AA-CYP450-EETs-sEH pathway in regulation of inflammation under different pathological conditions and discusses the existing challenges and future direction of this research field.

show abstract

“…Furthermore, inhibition of sEH has been used to treat rheumatoid arthritis by reducing nociception and inflammation, [ 67 ] to reduce inflammation and fibrosis in the host myocardium by inhibiting sEH, [ 68 ] and to improve vascular repair in the treatment of Kawasaki disease by inhibiting sEH. [ 69 ] sEH inhibitors have recently been shown to be effective in the treatment of sepsis.…”

Section: Sehi and Resolution Of Inflammationmentioning

confidence: 99%

Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID‐19

Manickam

Meenakshisundaram²,

Pillaiyar

2021

Archiv der Pharmazie

View full text Add to dashboard Cite

Anti‐inflammatory, specialized proresolving mediators such as resolvins, protectins, maresins, and lipoxins derived from polyunsaturated acids may play a potential role in lung diseases as they protect different organs in animal disease models. Polyunsaturated fatty acids are an important resource for epoxy fatty acids (EET, EEQ, and EDP) that mediate a broad array of anti‐inflammatory and proresolving mechanisms, such as mitigation of the cytokine storm. However, epoxy fatty acids are rapidly metabolized by soluble epoxide hydrolase (sEH). In animal studies, administration of sEH inhibitors (sEHIs) increases epoxy fatty acid levels, reduces lung inflammation, and improves lung function, making it a viable COVID‐19 treatment approach. Thus, using sEHIs to activate endogenous resolution pathways might be a novel method to minimize organ damage in severe cases and improve outcomes in COVID‐19 patients. This review focuses on the use of sEH inhibitors to activate endogenous resolution mechanisms for the treatment of COVID‐19.

show abstract

Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats

Cited by 19 publications

References 72 publications

Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats

CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators

Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID‐19

Contact Info

Product

Resources

About