Peritoneal Collagen Type IV Concentration in Adenocarcinoma of the Gastrointestinal Tract and Its Relationship to Histological Differentiation, Metastasis, and Survival

Abstract

To determine if peritoneal collagen type IV levels could serve as a parameter for predicting metastasis and the subsequent course of disease, the concentration of collagen IV in the peritoneal fluid of 85 patients with adenocarcinoma of the gastrointestinal tract, including 50 with gastric cancer and 35 with colorectal cancer, was measured radioimmunologically. The peritoneal collagen type IV levels were elevated in 13 (26%) of the patients with gastric cancer, in 8 (23%) of those with colorectal cancer, and in none of the control subjects. The mean concentration of collagen type IV in tumors characterized by peritoneal dissemination was significantly higher than that in those without metastasis; however, there were no significant differences in the collagen type IV levels between tumors with and those without liver metastasis, or between those with and those without lymph node metastasis. There was a significant correlation between the peritoneal collagen type IV level and survival time in patients with clinically evident peritoneal dissemination. A positive correlation was also found between collagen type IV and carcinoembryonic antigen levels. In conclusion, the levels of peritoneal collagen type IV provide evidence of peritoneal dissemination, and can aid in the prediction of life expectancy in patients with adenocarcinomas of the gastrointestinal tract.

Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic Cholangiocarcinoma of Syrian Golden Hamsters Induced by Clonorchis sinensis and N-Nitrosodimethylamine

“…Tumor cell survival, proliferation, and migration are highly dependent on ECM and collagen type IV which may serve as permissive substrates for tumor cell migration [ 30 ]. In gastrointestinal adenocarcinoma, elevated collagen IV level in peritoneal sample significantly associated with poor prognosis [ 31 ]. Therefore the presence of type IV collagen in the stroma of CCA might be due to the advancement of malignant CCA.…”

Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer

“…Although the role of type IV collagen in angiogenesis and cancer progression has been extensively studied, few have evaluated this protein as a potential biomarker. However, a correlation between levels of type IV collagen in peritoneal fluid and survival time in patients with peritoneal disseminated gastric and colorectal cancer has been shown (Korenaga et al, 1998).…”

Significance of Elevated Levels of Collagen Type IV and Hyaluronic Acid in Gastric Juice and Serum in Gastric Cancer and Precancerous Lesion

“…With the degradation of collagen type IV in BM and high levels of collagen type IV expression in close proximity to cancer cells in the tumor stroma, patients with cancer also have significantly high circulating levels of collagen type IV [15,16], and even the peritoneal collagen type IV levels were elevated within the patients with gastric cancer and colorectal cancer. The levels of collagen type IV in body fluid were significantly correlated with survival time [17].…”