Significance of Elevated Levels of Collagen Type IV and Hyaluronic Acid in Gastric Juice and Serum in Gastric Cancer and Precancerous Lesion

Abstract

The analysis of collagen type IV and HA in gastric juice and serum may provide a simple aid in diagnosing gastric cancer and evaluating whether metastasis is occurring or not.

Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases

“…We think the higher MDA levels are related to previous gastric cancer status rather than biliary reactive gastritis after gastrectomy because MDA levels are not correlated with reactive gastritis demonstrated by previous study 12. Prostaglandin, hyaluronic acid, aromatic amino acids as well as RNA assay are also showed higher levels in gastric juice of patients with gastric cancer 16,17,29,30. CA 19-9 and CEA levels in gastric fluid have no diagnostic and prognostic value in patients with gastric cancer 27.…”

“…15,28 Prostaglandin, hyaluronic acid, aromatic amino acids as well as RNA assay are also showed higher levels in gastric juice of patients with gastric cancer. 16,17,29,30 However, the optimal methods are still lacking because no existing gastric cancer biomarker in gastric juice has been carefully validated on a large scale. In the present study, we focus on the peroxidation process of gastric mucosal injury and demonstrated positive correlation…”

“…[15][16][17][18] But few studies have focus on the MDA levels in gastric juice and its relationship with stomach diseases. [15][16][17][18] But few studies have focus on the MDA levels in gastric juice and its relationship with stomach diseases.…”

“…Previous studies have used the levels of alpha1-antitrypsin, collagen, prostaglandins, and microRNA in gastric juice as potential biomarkers for early detection of gastric cancer. [15][16][17][18] But few studies have focus on the MDA levels in gastric juice and its relationship with stomach diseases. The purpose of our study was to investigate the association between gastric juice MDA levels and stomach diseases, including H. pylori infection, gastric intestinal metaplasia, and gastric cancer postsurgical resection status.…”

COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas

“…Down-regulated collagen IV expression was directly related to high histologic grade [18]. Patients with gastric cancer with lymph node metastasis had more collagen type IV than patients without metastases [29]. A positive link between COL4A3 expression and progression of gastric carcinoma indicated that COL4A3 could be used as a marker to measure the aggressiveness of gastric carcinomas.…”